Abstract 140
Aim: Filling the lung with PFC in partial liquid ventilation (PLV) could affect hemodynamics and thus cerebral oxygenation. Because of the clinical relevance, the effect of the PFC-amount on cerebral oxygenation was tested.
Methods: After surfactant depletion newborn pigs (median 950g) were conventionally ventilated for 1h (CMV), PLV was started with 10 or 30 ml/kg PF 5080 and continued for 2h, evaporative losses of PFC were substituted. Beside hemodynamic parameters, changes in cerebral concentrations of HbO2/Hb were measured using the NIRS (NIRO 500, Hamamatsu Photonics).
Results: Systemic oxygenation improved in both groups after initiation of PLV. After 20 min of PLV pigs with 10ml/kg had a significantly higher HbO2 concentration. In the 30ml group it was even lower than during CMV. (Table)
Discussion: In infants filling of the lung with an amount of PFC equal to FRC (30 ml/kg) could have a negative influence on cerebral oxygenation. 10 ml/kg will be appropriate to improve oxygenation without negative effects.
Supported by BMBF "Perinatale Lunge-01ZZ9511"
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Rüdiger, M., Burkhardt, W., Proquitté, H. et al. Liquid Ventilation with 10 ml/kg improves cerebral oxygen delivery. Pediatr Res 45, 910 (1999). https://doi.org/10.1203/00006450-199906000-00158
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DOI: https://doi.org/10.1203/00006450-199906000-00158
