Unrelated Bmt for Severe Haematological Malignancies: Comparison of Results in Matched and Mismatched Pairs

Abstract • 161

We present results of unrelated bone marrow transplantations (BMT) performed in 37 children who suffered from severe hematological malignancies: 18 ALL, 8 AML, 5 RAEBt, 1 RAEB, 1 JCML, 1 MDS, 2 CML, 1 T NHL. High resolution subtypings for HLA- A, B, C, DR, DQ loci were determined retrospectively for 19 pairs and at time of donor selection for 18 pairs. Conditioning regimen was standard with chemotherapy alone (n = 10) or associated with TBI (n = 27). Rabbit Anti lymphocyte globulin Merieux was added in 27 cases. One patient received T cell depleted marrow. Population is divided into 2 groups : 1^st group with 18/37 HLA identical (ID) pairs (DP excluded) (49 %) and 2^nd group with 19/37 pairs presenting from 1 to 3 allelic or antigeneic mismatches (51 %) (DP excluded). Results are as follows : (Table)

Table 1 No caption available.

Post BMT event are equivalent in the 2 groups. For the whole group, overall survival is 65 % at 3 years. Relapse free survival is 66 % at 3 years for the 1^st group and 62 % at 3 years for 2nd group (p = 0,67) which leads us to perform unrelated mismatched BMT in absence of HLA identical donor location.