Human milk (HM) has long chain polynsaturated fatty acids (LCPUFA) with an n-3/n-6 ratio which is different from artificial formula. Previous studies have shown a decrease in membrane LCPUFA in premature infants fed formula devoid of LCPUFA. We have studied the effect of early diet on FA membrane composition in 11 premature babies fed HM. Lipids were extracted, FA were methylated and quantitated using capillary GC (HP 5890 Chomatigraph) and FID detection. The results of red cells at 32 1/2, 36, 40 and 57 wks post-concepcional age are reported as mean ±% total.Table Premature infants fed HM have a membrane lipid composition with higher DHA (22:6 n-3) and AA (20:4 n-6) than published references derived from formula fed infants. (Hoffman D, Uauy R. 1992. Lipids:27:886-95) supported by Fondecyt 1930820.

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