Enhancing the efficiency of solar-driven water splitting is challenging but highly interesting. Here the authors report a dual spin-controlled 2D/3D perovskite photoelectrode that achieves 12.55% efficiency by utilizing the chiral-induced spin selectivity phenomenon.

Machine learning-assisted robots produce MXene aerogels containing cellulose, gelatin, and glutaraldehyde, fabricating 162 compositions. Inverse design from resulting properties affords tailored compression-stable materials for Joule heating.

Palladium-based catalysts are highly effective for the complete oxidation of methane. Here, the authors employ operando transmission electron microscopy, near-ambient pressure X-ray photoelectron spectroscopy, and density functional theory calculations to investigate the active state and catalytic function of Pd nanoparticles in methane oxidation.

Room temperature phosphorescent polymers have potential in a range of applications, but achieving the desired properties can be challenging. Here, the authors report the development of such polymer materials by doping with polyaromatic hydrocarbons.

This work reports a single-atom Ni incorporated CeO₂ catalyst that boosts the efficiency of solar CO₂ reduction under concentrated light irradiation.

Results show meaningful variations in electric vehicle costs and emissions benefits across the United States, differing by vehicle category and charging systems: Direct Current Fast Charging, Battery Swapping, and Dynamic Wireless Power Transfer.

This study maps global tree composition in forests and assesses the impacts of historical forest cover loss and climate change. The results highlight the need for preserving the remaining large forest biomes, while regenerating degraded forests in a way that provides resilience against climate change.

Estimating weather-induced shocks on food production requires reliable global weather datasets. Here, the authors compare global (GMFD and ERA5-Land) and regional (PRISM) datasets, showing that global datasets can uncover non-linear temperature relationships despite their lower predictive skill.

Zhang et al. propose the ecological status of the ocean by considering microbial diversity, structure, and biogeochemical potential. Ecological status of 32.44% surface ocean will change due to climate change in 2100, assuming no policy intervention.

Alternative stable states in forests have implications for the biosphere. Here, the authors combine forest biodiversity observations and simulations revealing that leaf types across temperate regions of the NH follow a bimodal distribution suggesting signatures of alternative forest states.

Activated GPCRs signal through multiple pathways. Ligands that signal through a single pathway are highly valued. The authors demonstrate that tethering ligands to receptors via conjugation with binding nanobodies enables pathway-specific signaling.

Self-tolerance is established during B cell development but the contribution of clonal deletion, receptor editing, anergy and apoptosis is debated. Here we show that although apoptosis does occur in a high proportion of transitional B cells after exiting the bone marrow, the reactivity of apoptotic B cells does not differ from that of viable cells, which argues against apoptosis as major mechanism to eliminate self-reactive and polyreactive clones.

Engineering natural microbiomes for biotechnological applications remains challenging. Here, the authors present a combinatory top-down and bottom-up framework to engineer natural microbiomes for the construction of function-enhanced synthetic microbiomes.

Mitochondrial tRNAs are less structurally stable than nuclear tRNAs, and their maturation pathway is unique. Here, the authors reveal how human mitochondrial precursor tRNAs are recognised, processed, methylated and prepared for full functionality in mitochondrial translation.

This study presents EMDiffuse, a software suite based on diffusion models which augments electron microscopy imaging. EMDiffuse enhances electron microscopy images and enables isotropic reconstruction of volume electron microscopy data, suitable for investigating biological nanostructures.

Here, the authors develop a deep-learning algorithm to predict biomarkers from histopathological imaging in advanced urothelial cancer patients. This method detects suitable patients for targeted therapy clinical trials with a significant reduction in molecular testing, providing cost and time savings in real-world clinical settings.

Elevation of IL-6 during cancer progression has been shown to drive cancer cachexia, however, while brain dysfunction has been reported, the underlying mechanism is unclear. Here, the authors identify neurons in the area postrema as a mediator of peripheral IL-6 in preclinical models of cancer cachexia.

Variants of the 3′−5′ exonuclease TREX1 can cause retinal vasculopathy with cerebral leukoencephalopathy (RVCL). Here, the authors show that RVCL-associated TREX1 variants trigger DNA damage in humans, mice, and Drosophila, and render cells more vulnerable to DNA damage inducing agents.

Central memory CD8+ T cells (Tcm) are important for lasting anti-tumour immunity and their differentiation is determined by underpinning transcriptional and metabolic regulation. Authors here show that although microwave ablation (MWA) cancer therapy induces T cells to acquire some of the gene expression features of Tcms, but the full metabolic remodeling required for functionality is only achieved if glycolysis is inhibited simultaneously.

Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.

Modeled results show that rooftop solar reduced energy burden for most adopters in 2021 from a median of 3.3% to 2.6% with the average adopter seeing a 0.6 point ($691 annual) reduction in burden, accounting for costs, incentives, and savings.

Results show meaningful variations in electric vehicle costs and emissions benefits across the United States, differing by vehicle category and charging systems: Direct Current Fast Charging, Battery Swapping, and Dynamic Wireless Power Transfer.

Harnessing the potential of considerable food security efforts requires the ability to translate them into commercial applications. In this Perspective, the author explores the alternative protein source start-up landscape.

Decentralized management of distributed energy sources for lower energy costs is of high interest. Here, authors show how privacy and security concerns are addressed under a decentralization framework through blockchain and parallelizable algorithms.

Zhao P.J. and his colleagues uncover spatial directionality of urban mobility by using new metrics of anisotropy and centripetality. They find monocentric cities have longer commutes with city expansion, while polycentric cities maintain consistent commuting patterns.