Voltage clamp articles from across Nature Portfolio

Latest Research and Reviews

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  Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry

  Characterization of ASIC2a/3 heterotrimer stoichiometry reveals the physiologically relevant form and functional differences to ASIC1a/2a heterotrimers and ASIC homotrimers.

  • Leon Fischer
  • Axel Schmidt
  • Stefan Gründer

  ResearchOpen Access08 Jul 2023 Communications Biology

  Volume: 6, P: 701
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  Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1

  TRPV1 is a noxious heat sensor. Here, authors showed that tailed amphibians express TRPV1 with a reduced heat-activation threshold by substitution of two amino acids in the N-terminal region to contribute to cool-habitat selection.

  • Shogo Hori
  • Michihiro Tateyama
  • Osamu Saitoh

  ResearchOpen Access11 May 2023 Nature Communications

  Volume: 14, P: 2415
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  Gating and ion selectivity of Channelrhodopsins are critical for photo-activated orientation of Chlamydomonas as shown by in vivo point mutation

  Channelrhodopsin photoreceptors are responsible for phototaxis in C. reinhardtii. Here, authors introduce point mutations in the channel which modify photocycle kinetics and ion selectivity, resulting in a deeper understanding of phototaxis in low light conditions.

  • Olga Baidukova
  • Johannes Oppermann
  • Peter Hegemann

  ResearchOpen Access25 Nov 2022 Nature Communications

  Volume: 13, P: 7253
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  Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel

  Fluorometry signals indicating conformational change in an ion channel are generated by quenching amino acids and lipid effects during movement of the dye relative to the plane of the membrane.

  • Ferenc Papp
  • Gilman E. S. Toombes
  • Zoltan Varga

  ResearchOpen Access26 Oct 2022 Communications Biology

  Volume: 5, P: 1131
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  A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling

  Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur that prohibit the formation of a conductive intermediate state conformation of the voltage sensor.

  • Xiaoan Wu
  • Marta E. Perez
  • H. Peter Larsson

  ResearchOpen Access20 Jul 2021 Communications Biology

  Volume: 4, P: 887
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  Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei

  • Sami Havukainen
  • Jonai Pujol-Giménez
  • Christopher P. Landowski

  ResearchOpen Access19 Jul 2021 Scientific Reports

  Volume: 11, P: 14678