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Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
- Sean F. Cooke
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A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
- Lauren M. Weaver
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The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer
- Takaomi Hagi
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Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
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Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Radix Astragali against hypopharyngeal carcinoma
- Jianing Zhang
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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo
- Elizabeth J. Brown
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Network pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
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Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators
- Anastasia Schultz
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- & Frances Lefcort
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Binding affinity predictions with hybrid quantum-classical convolutional neural networks
- L. Domingo
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Anti-methicillin-resistant Staphylococcus aureus activity and safety evaluation of 14-O-[(5-ethoxycarbonyl-4,6-dimethylpyrimidine-2-yl) thioacetyl] mutilin (EDT)
- Yuhang Zhou
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Tamoxifen associated to the conservative CKD treatment promoted additional antifibrotic effects on experimental hypertensive nephrosclerosis
- Camilla Fanelli
- , Ana L. R. Francini
- & Irene L. Noronha
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Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management
- P. C. Agu
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Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases
- Jan Kägi
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Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
- Wiebke Obermann
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Real-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry
- Nadine Colé
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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
- Mikolaj Zmudzinski
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A publication-wide association study (PWAS), historical language models to prioritise novel therapeutic drug targets
- David Narganes-Carlón
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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
- Kathleen J. Till
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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
- Leah Amod
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In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor
- Asma Gholami
- , Dariush Minai-Tehrani
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Expression of membrane Hsp90 is a molecular signature of T cell activation
- Scott A. Scarneo
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Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer
- Nawel Mekdad
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Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
- Andrew A. Bieberich
- , Tuomo Laitinen
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Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models
- Benjamin Strobel
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Irigenin, a novel lead from Iris confusa for management of Helicobacter pylori infection with selective COX-2 and HpIMPDH inhibitory potential
- Passent M. Abdel-Baki
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In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19
- Nabih A. Baeshen
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The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors
- Kotaro Sakamoto
- , Bangzhong Lin
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Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
- Maria L. Faquetti
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Efficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19
- Vincenzo Messina
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Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism
- Romano Strobelt
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Potential of [11C]UCB-J as a PET tracer for islets of Langerhans
- Emmi Puuvuori
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Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells
- Hung Caohuy
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- & Harvey B. Pollard
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Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
- Adam J. Davenport
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Curcumin inhibited hepatitis B viral entry through NTCP binding
- Piyanoot Thongsri
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A forward genetic screen identifies modifiers of rocaglate responsiveness
- Leo Shen
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Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy
- Samantha T. Reyes
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- & Frederick T. Chin
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Rapid target validation in a Cas9-inducible hiPSC derived kidney model
- Yasaman Shamshirgaran
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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
- Sohaib Nizami
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Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement
- Atsushi Suzuki
- , Akiyoshi Kunugi
- & Haruhide Kimura
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Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor
- Michael C. Babcock
- , Christina R. Mikulka
- & Brett E. Crawford
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Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells
- Gautier Follain
- , Naël Osmani
- & Jacky G. Goetz
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A novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
- S. Kiruthika
- , Ruchika Bhat
- & B. Jayaram
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In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα
- Benjamin Xiaoyi Li
- , Xiangrong Dai
- & Heyu Ni
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Evaluation method for asymmetric uncertainty of quantitative polymerase chain reaction measurements of deoxyribonucleic acids with low copy number
- Unoh Ki
- , Takeru Suzuki
- & Hirotaka Unno
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Article
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Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers
- Martina Meßner
- , Melanie M. Mandl
- & Johanna Pachmayr
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Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics
- James M. McCarthy
- , Jasmeet Virdee
- & Hugh N. Nuthall
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Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase
- Syed Hani Abidi
- , Nahlah Makki Almansour
- & Syed Ali
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Elucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models
- Tongxing Wang
- , Lu Liang
- & Yunhui Hu
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A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia