Sequencing articles within Nature Communications

Featured

• Article
  27 December 2012 | Open Access

  The genome of Prunus mume

  The Prunus mume was domesticated in China over 3,000 years ago and is an important ornamental plant and fruit. Here Qixiang Zhang et al.obtain the first assembly of its genome with a combination of next-generation sequencing, whole-genome mapping and restriction-site-associated DNA.

  • Qixiang Zhang
  • , Wenbin Chen
  •  & Jun Wang

• Article | 04 December 2012

  A fast and accurate SNP detection algorithm for next-generation sequencing data

  The amount of data supplied by next-generation sequencing technologies presents a challenge for traditional algorithms to detect single-nucleotide polymorphisms. Xu et al.develop an efficient detection program and demonstrate its utility by identifying polymorphisms in cancer genomes and human populations.

  • Feng Xu
  • , Weixin Wang
  •  & Junwen Wang

• Article
  13 November 2012 | Open Access

  Genome sequences of wild and domestic bactrian camels

  Camels are essential means of transport in deserts, but we know little about the biology of these extraordinary mammals. This study reports the genome sequences of the wild and domestic bactrian camel, offering a glimpse into the camels’ genetic adaptation to harsh environments.

  • Jirimutu
  • , Zhen Wang
  •  & He Meng

• Article
  26 June 2012 | Open Access

  Genome sequence of the model medicinal mushroom Ganoderma lucidum

  Ganoderma lucidumis a macrofungus in traditional Chinese medicine known to produce different bioactive compounds. In this study, the genome ofG. lucidumis sequenced, making this organism a potential model system for future studies of secondary metabolic pathways and their regulation in medicinal fungi.

  • Shilin Chen
  • , Jiang Xu
  •  & Chao Sun

• Article | 28 February 2012

  Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation

  Influenza vaccines are updated frequently to accommodate changing influenza antigenicity. Here, the authors develop a new computational method for predicting the antigenicity of H3N2 influenza strains based on the HA sequence.

  • Xiangjun Du
  • , Libo Dong
  •  & Taijiao Jiang

• Article | 23 August 2011

  Discovery of lost diversity of paternal horse lineages using ancient DNA

  Modern female horses are genetically diverse but male horses are relatively homogenous. Lippoldet al. sequence the Y chromosome of nine ancient horses and detect diversity in the ancestral paternal lineage, demonstrating ancient Y-chromosomal DNA sequencing can provide insights into evolution.

  • Sebastian Lippold
  • , Michael Knapp
  •  & Michael Hofreiter

• Article
  17 May 2011 | Open Access

  Predicting sites of ADAR editing in double-stranded RNA

  ADAR enzymes edit double-stranded RNA, converting adenosines to inosines, and are essential for neuronal function. Eggingtonet al. quantify edit sites in RNA using a Sanger sequencing protocol and use the resulting data to develop algorithms to predict RNA edit sites.

  • Julie M. Eggington
  • , Tom Greene
  •  & Brenda L. Bass

• Article
  30 November 2010 | Open Access

  Deep resequencing reveals excess rare recent variants consistent with explosive population growth

  To fully catalogue rare genetic variation in humans, many samples need to be examined. In this study, Coventryet al. resequenced two genes, KCNJ11 and HHEX, in 13,715 humans, and concluded that most of the sequence variation arose recently and that variation is greater than expected.

  • Alex Coventry
  • , Lara M. Bull-Otterson
  •  & Charles F. Sing