Renal calculi articles within Nature Communications

Featured

• Article
  19 July 2023 | Open Access

  A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

  Kidney stone disease causes significant morbidity and increases in health care utilization. Here, the authors define the spatial molecular landscape and specific pathways contributing to stone-mediated injury in the human renal papilla and identify associated urinary biomarkers.

  • Victor Hugo Canela
  • , William S. Bowen
  •  & Tarek M. El-Achkar

• Article
  15 November 2019 | Open Access

  Genetic variants of calcium and vitamin D metabolism in kidney stone disease

  Kidney stones form in the presence of overabundance of crystal-forming substances such as Ca²⁺ and oxalate. Here, the authors report genome-wide association analyses for kidney stone disease, report seven previously unknown loci and find that some of these loci also associate with Ca²⁺ concentration and excretion.

  • Sarah A. Howles
  • , Akira Wiberg
  •  & Dominic Furniss

• Article
  03 October 2017 | Open Access

  A non-classical view on calcium oxalate precipitation and the role of citrate

  The formation mechanism of abundant calcium oxalate biomaterials is unresolved. Here the authors show the early stages of calcium oxalate formation in pure and citrate-bearing solutions by using a titration set-up in conjunction with solution quenching, transmission electron microscopy and analytical ultracentrifugation.

  • Encarnación Ruiz-Agudo
  • , Alejandro Burgos-Cara
  •  & Carlos Rodriguez-Navarro