Featured
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Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Using single-cell lineage tracing, the authors identify TCF15 as a novel regulator of haematopoietic stem cell quiescence and self-renewal.
- Alejo E. Rodriguez-Fraticelli
- , Caleb Weinreb
- & Fernando D. Camargo
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Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Stress induces hair greying in mice through depletion of melanocyte stem cells, which is mediated by the activation of sympathetic nerves rather than through immune attack or adrenal stress hormones.
- Bing Zhang
- , Sai Ma
- & Ya-Chieh Hsu
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Letter |
Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.
- Meryem B. Baghdadi
- , David Castel
- & Philippos Mourikis
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Autophagy maintains the metabolism and function of young and old stem cells
Loss of autophagy increases the accumulation of mitochondria and the respiration status of haematopoietic stem cells, which perturbs their self-renewal and regeneration activities, and promotes cellular aging.
- Theodore T. Ho
- , Matthew R. Warr
- & Emmanuelle Passegué
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Letter |
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Here, DNA damage is shown to occur as a direct consequence of inducing haematopoietic stem cells to exit quiescence in response to conditions of stress; in mice with mutations modelling those seen in Fanconi anaemia, this leads to a complete collapse of the haematopoietic system.
- Dagmar Walter
- , Amelie Lier
- & Michael D. Milsom
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Article |
Geriatric muscle stem cells switch reversible quiescence into senescence
This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16INK4a is identified as a common feature of senescent satellite cells.
- Pedro Sousa-Victor
- , Susana Gutarra
- & Pura Muñoz-Cánoves
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Letter |
The microRNA miR-235 couples blast-cell quiescence to the nutritional state
A microRNA, miR-235, is identified that acts downstream of the insulin/insulin growth factor signalling pathway to modulate the quiescence of blast cells in Caenorhabditis elegans.
- Hidefumi Kasuga
- , Masamitsu Fukuyama
- & Toshiaki Katada
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Article |
Intestinal label-retaining cells are secretory precursors expressing Lgr5
A new method to trace the lineage of slow cycling label-retaining cells (LRCs) in vivo identifies a population of LRCs that have features of committed Paneth cells but still express stem-cell markers such as Lgr5; the slow cycling cells differentiate into Paneth cells without cell division, but after injury can also repopulate the stem-cell niche and contribute to the regeneration of all intestinal lineages.
- Simon J. A. Buczacki
- , Heather Ireland Zecchini
- & Douglas J. Winton