Article
|
Open Access
Featured
-
-
Article
| Open AccessIn silico design and optimization of selective membranolytic anticancer peptides
- Gisela Gabernet
- , Damian Gautschi
- & Gisbert Schneider
-
Article
| Open AccessGolden Mutagenesis: An efficient multi-site-saturation mutagenesis approach by Golden Gate cloning with automated primer design
- Pascal Püllmann
- , Chris Ulpinnis
- & Martin J. Weissenborn
-
Article
| Open AccessDevelopment of latent Interferon alpha 2b as a safe therapeutic for treatment of Hepatitis C virus infection
- Iram Gull
- , Muhammad Shahbaz Aslam
- & Muhammad Amin Athar
-
Article
| Open AccessUse of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein
- Chien-Chiao Huang
- , Kai-Wen Cheng
- & Tian-Lu Cheng
-
Article
| Open AccessSingle-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography
- Dongsheng Lei
- , Jianfang Liu
- & Gang Ren
-
Article
| Open AccessDevelopment of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage
- Dung Thanh Dang
- & Anh Tuân Phan
-
Article
| Open AccessThe Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function
- Sophie M. C. Gobeil
- , Maximillian C. C. J. C. Ebert
- & Joelle N. Pelletier
-
Article
| Open AccessStructure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy
- Ragan Pitner
- , Jiho Kim
- & Sean A. Gray
-
Article
| Open AccessPosition 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity
- Jennifer Solarczek
- , Thomas Klünemann
- & Anett Schallmey
-
Article
| Open AccessAn engineered GH1 β-glucosidase displays enhanced glucose tolerance and increased sugar release from lignocellulosic materials
- Clelton A. Santos
- , Mariana A. B. Morais
- & Anete P. Souza
-
Article
| Open AccessInhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
- Arumay Pal
- , Kurt Neo
- & Alessandra Mortellaro
-
Article
| Open AccessBacteriophage T4 capsid as a nanocarrier for Peptide-N-Glycosidase F immobilization through self-assembly
- Liang Zhang
- , Pei Wang
- & Xin Liu
-
Article
| Open AccessExploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations
- Kouhei Yoshida
- , Daisuke Kuroda
- & Kouhei Tsumoto
-
Article
| Open AccessReactive centre loop dynamics and serpin specificity
- Emilia M. Marijanovic
- , James Fodor
- & Ashley M. Buckle
-
Article
| Open AccessA bio-coupling approach using a dextran-binding domain to immobilize an engineered streptavidin to Sephadex for easy preparation of affinity matrix
- Sau-Ching Wu
- , Chris Wang
- & Sui-Lam Wong
-
Article
| Open AccessThe IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface
- Adam H. Barczewski
- , Michael J. Ragusa
- & Maria Pellegrini
-
Article
| Open AccessSubstituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system
- Michael S. Lukesch
- , Tea Pavkov-Keller
- & Birgit Wiltschi
-
Article
| Open AccessDesigning a multi-epitope based vaccine to combat Kaposi Sarcoma utilizing immunoinformatics approach
- Varun Chauhan
- , Tripti Rungta
- & Mini P. Singh
-
Article
| Open AccessStructural basis for chemically-induced homodimerization of a single domain antibody
- Jean Lesne
- , Hung-Ju Chang
- & Martin Cohen-Gonsaud
-
Article
| Open AccessLigand-induced conformational switch in an artificial bidomain protein scaffold
- Corentin Léger
- , Thibault Di Meo
- & Philippe Minard
-
Article
| Open AccessDirected evolution of super-secreted variants from phage-displayed human Interleukin-2
- Gertrudis Rojas
- , Tania Carmenate
- & Kalet León
-
Article
| Open AccessSelection and Characterization of Anti-Dengue NS1 Single Domain Antibodies
- Lisa C. Shriver-Lake
- , Jinny L. Liu
- & Ellen R. Goldman
-
Article
| Open AccessDevelopment of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates
- Yi-Jou Chen
- , Michael Chen
- & Kuo-Hsiang Chuang
-
Article
| Open AccessComputational affinity maturation of camelid single-domain intrabodies against the nonamyloid component of alpha-synuclein
- Sai Pooja Mahajan
- , Bunyarit Meksiriporn
- & Matthew P. DeLisa
-
Article
| Open AccessEngineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance
- Saori Suzuki
- , Hiroaki Annaka
- & Ryutaro Asano
-
Article
| Open AccessEfficient silica synthesis from tetra(glycerol)orthosilicate with cathepsin- and silicatein-like proteins
- Natalia V. Povarova
- , Nikolay A. Barinov
- & Konstantin A. Lukyanov
-
Article
| Open AccessAffinity to cellulose is a shared property among coiled-coil domains of intermediate filaments and prokaryotic intermediate filament-like proteins
- Niklas Söderholm
- , Ala Javadi
- & Linda Sandblad
-
Article
| Open AccessStrategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form
- Benedetta Guidi
- , Matteo Planchestainer
- & Francesco Molinari
-
Article
| Open AccessDesign of metalloproteins and novel protein folds using variational autoencoders
- Joe G. Greener
- , Lewis Moffat
- & David T Jones
-
Article
| Open AccessA highly stable laccase obtained by swapping the second cupredoxin domain
- Isabel Pardo
- , David Rodríguez-Escribano
- & Susana Camarero
-
Article
| Open AccessHumanization of Antibodies using a Statistical Inference Approach
- Alejandro Clavero-Álvarez
- , Tomas Di Mambro
- & Pierpaolo Bruscolini
-
-
Article
| Open AccessDevelopment of Bacillus methanolicus methanol dehydrogenase with improved formaldehyde reduction activity
- Jiyeun Yi
- , Jinhyuk Lee
- & Jung-Hoon Sohn
-
Article
| Open AccessComputer-Guided Surface Engineering for Enzyme Improvement
- Matthew Wilding
- , Colin Scott
- & Andrew C. Warden
-
Article
| Open AccessNovel 3D Structure Based Model for Activity Prediction and Design of Antimicrobial Peptides
- Shicai Liu
- , Jingxiao Bao
- & Heng Zheng
-
Article
| Open AccessCrystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture
- Kaare Bjerregaard-Andersen
- , Hedda Johannesen
- & Ute Krengel
-
Article
| Open AccessImproving catalytic activity of the Baeyer–Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid
- Ji-Min Woo
- , Eun-Yeong Jeon
- & Jin-Byung Park
-
Article
| Open AccessSynthetic antigen-binding fragments (Fabs) against S. mutans and S. sobrinus inhibit caries formation
- Md. Kausar Alam
- , Li Zheng
- & C. Ronald Geyer
-
Article
| Open AccessStructural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase
- Seiji Negoro
- , Naoki Shibata
- & Yoshiki Higuchi
-
Article
| Open AccessTransient AID expression for in situ mutagenesis with improved cellular fitness
- Talal Salem Al-Qaisi
- , Yu-Cheng Su
- & Steve R. Roffler
-
Article
| Open AccessSubtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii
- Vandana Solanki
- & Vishvanath Tiwari
-
Article
| Open AccessEngineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5
- Yosuke Hashimoto
- , Wei Zhou
- & Hiroyuki Takeda
-
Article
| Open AccessIgG-single-chain TRAIL fusion proteins for tumour therapy
- Martin Siegemund
- , Felix Schneider
- & Roland E. Kontermann
-
Article
| Open AccessDiscovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy
- Qiyue Hu
- , Xin Ye
- & Weikang Tao
-
Article
| Open AccessStructure-guided Discovery of Dual-recognition Chemibodies
- Alan C. Cheng
- , Elizabeth M. Doherty
- & Zhulun Wang
-
Article
| Open AccessQM/MM free energy Simulations of an efficient Gluten Hydrolase (Kuma030) Implicate for a Reactant-State Based Protein-Design Strategy for General Acid/Base Catalysis
- Xia Wang
- , Ruirui Li
- & Jianzhuang Yao
-
Article
| Open AccessMolecular design of radiocopper-labelled Affibody molecules
- Vladimir Tolmachev
- , Tove J. Grönroos
- & Amelie Eriksson Karlström
-
Article
| Open AccessComputational Protein Design with Deep Learning Neural Networks
- Jingxue Wang
- , Huali Cao
- & Yifei Qi
-
Article
| Open AccessCrystal structure of Bacillus cereus flagellin and structure-guided fusion-protein designs
- Meong Il Kim
- , Choongdeok Lee
- & Minsun Hong