Preventive medicine

Article | 13 December 2023

Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

An inhalable, single-dose dry powder aerosol SARS-CoV-2 vaccine shows good storage stability, results in sustained antigen delivery to antigen-presenting cells in the lungs and induces a potent antiviral immune response.

Tong Ye
, Zhouguang Jiao
& Wei Wei

Article | 09 December 2021

The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
, Shoa L. Clarke
& Cristen J. Willer

Article | 27 May 2021

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

In a phase-I/II trial in healthy adults, the BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells against SARS-CoV-2 epitopes that are conserved in a wide range of currently circulating variants.

Ugur Sahin
, Alexander Muik
& Özlem Türeci

Article | 26 May 2020

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

Rui Shi
, Chao Shan
& Jinghua Yan

Article | 04 May 2020

Effect of non-pharmaceutical interventions to contain COVID-19 in China

A model of the effects of different non-pharmaceutical interventions on the spread of COVID-19 in China suggests that a strategy involving the rapid implementation of a combination of interventions is most effective.

Shengjie Lai
, Nick W. Ruktanonchai
& Andrew J. Tatem

Letter | 31 July 2019

A clinically applicable approach to continuous prediction of future acute kidney injury

A deep learning approach that predicts the risk of acute kidney injury may help to identify patients at risk of health deterioration within a time window that enables early treatment.