Featured
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Article |
New gene functions in megakaryopoiesis and platelet formation
A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.
- Christian Gieger
- , Aparna Radhakrishnan
- & Nicole Soranzo
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Research Highlights |
Platelets signal cells to invade
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Research Highlights |
Immune system's bacterial shepherd
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Research Highlights |
Stem cells: Platelets get a boost
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Letter |
A mechanically stabilized receptor–ligand flex-bond important in the vasculature
Here, a new type of behaviour of receptor–ligand bonds has been identified, by using a new method that links receptor and ligand in a single molecule to measure binding and unbinding. The binding of von Willebrand factor to the glycoprotein Ib α subunit on the surface of platelets is important for coagulation. This receptor–ligand bond is now shown to have two distinct states, one seen at low force and a second that has greater force resistance. This has implications for how increased blood flow activates platelet plug formation.
- Jongseong Kim
- , Cheng-Zhong Zhang
- & Timothy A. Springer
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors