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A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel
The cryo-electron microscopy structure of the membrane-embedded ubiquitin ligase complex reveals its function as a retrotranslocation channel for shuttling mobile receptors out of peroxisomes.
- Peiqiang Feng
- , Xudong Wu
- & Tom A. Rapoport
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Article |
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.
- Yilong Zou
- , Whitney S. Henry
- & Stuart L. Schreiber
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Letter |
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
Peroxisomes—tiny intracellular organelles that contain metabolic enzymes—are generated in mammalian cells by the fusion of structures that arise from both mitochondria and the endoplasmic reticulum.
- Ayumu Sugiura
- , Sevan Mattie
- & Heidi M. McBride
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Letter |
Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi
Translocation of glycolytic enzymes to peroxisomes in fungi suggests broader metabolic role for this organelle.
- Johannes Freitag
- , Julia Ast
- & Michael Bölker
Peroxisome biogenesis initiated by protein phase separation