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| Open AccessVagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope
The molecular mechanisms underlying the Bezold–Jarisch reflex and syncope (fainting) involve vagal sensory neurons that express neuropeptide Y receptor Y2, the deletion of which in animal models abolishes the Bezold–Jarisch reflex.
- Jonathan W. Lovelace
- , Jingrui Ma
- & Vineet Augustine
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Article |
Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut
A subpopulation of cholinergic neurons triggers Ca2+ currents among enterocytes to promote return to homeostasis after injury, and disruption of this process leads to gut inflammation and hyperplasia in Drosophila.
- Afroditi Petsakou
- , Yifang Liu
- & Norbert Perrimon
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Article |
Dedicated macrophages organize and maintain the enteric nervous system
Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive function, indicating that the ENS is governed by a dedicated population of resident macrophages that adapt to the timely needs of the ENS.
- Maria Francesca Viola
- , Marta Chavero-Pieres
- & Guy Boeckxstaens
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Article
| Open AccessAn airway-to-brain sensory pathway mediates influenza-induced sickness
A small population of prostaglandin E2-responsive glossopharyngeal sensory neurons provides a sensory pathway between airway and brainstem that mediates sickness responses to early-phase influenza virus infection.
- Na-Ryum Bin
- , Sara L. Prescott
- & Stephen D. Liberles
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Article
| Open AccessA brainstem map for visceral sensations
In vivo two-photon calcium imaging analyses of sensory inputs from the gastrointestinal tract and upper airways in mice reveal spatial organization and coding principles of the interoceptive nervous system.
- Chen Ran
- , Jack C. Boettcher
- & Stephen D. Liberles
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Article
| Open AccessThe role of somatosensory innervation of adipose tissues
Beige-fat-innervating sensory neurons modulate adipocyte function by acting as a brake on the sympathetic system.
- Yu Wang
- , Verina H. Leung
- & Li Ye
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Article
| Open AccessPIEZO1 transduces mechanical itch in mice
Experiments in mice show that the mechanically activated ion channel PIEZO1 is expressed in itch-specific sensory neurons and has a role in transducing mechanical itch.
- Rose Z. Hill
- , Meaghan C. Loud
- & Ardem Patapoutian
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Article
| Open AccessNeuropathic pain caused by miswiring and abnormal end organ targeting
Longitudinal imaging of nerve fibres in mice reveals that reinnervation after nerve injury can lead to neuropathic pain, which is mediated through aberrant patterns of reinnervation in denervated areas by nociceptors.
- Vijayan Gangadharan
- , Hongwei Zheng
- & Rohini Kuner
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Article
| Open AccessA multidimensional coding architecture of the vagal interoceptive system
Single-cell profiling of vagal sensory neurons from seven organs in mice and calcium-imaging-guided spatial transcriptomics reveal that interoceptive signals are coded through three distinct dimensions, allowing efficient processing of multiple signals in parallel using a combinatorial strategy.
- Qiancheng Zhao
- , Chuyue D. Yu
- & Rui B. Chang
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Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
An epidural spinal cord stimulation system regulates blood pressure in the acute and chronic phases of spinal cord injury.
- Jordan W. Squair
- , Matthieu Gautier
- & Aaron A. Phillips
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Article |
Nociceptive nerves regulate haematopoietic stem cell mobilization
Stimulation of pain-sensing neurons, which can be achieved in mice by the ingestion of capsaicin, promotes the migration of haematopoietic stem cells from the bone marrow into the blood.
- Xin Gao
- , Dachuan Zhang
- & Paul S. Frenette
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Article |
PIEZO2 in sensory neurons and urothelial cells coordinates urination
PIEZO2 is expressed in the bladder urothelium and sensory neurons innervating the lower urinary tract and is a key mechanosensor for the control of urination.
- Kara L. Marshall
- , Dimah Saade
- & Ardem Patapoutian
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Matters Arising |
Heat detection by the TRPM2 ion channel
- Bruno Vilar
- , Chun-Hsiang Tan
- & Peter A. McNaughton
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Article |
A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue
The authors show that leptin signalling regulates the plasticity of sympathetic architecture of adipose tissue via a top-down neural pathway that is crucial for energy homeostasis.
- Putianqi Wang
- , Ken H. Loh
- & Jeffrey Friedman
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Article |
γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis
Vγ6+ Vδ1+ γδ T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice.
- Bo Hu
- , Chengcheng Jin
- & Bruce M. Spiegelman
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Article |
Neuronal programming by microbiota regulates intestinal physiology
In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.
- Yuuki Obata
- , Álvaro Castaño
- & Vassilis Pachnis
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Habenular TCF7L2 links nicotine addiction to diabetes
The transcription factor TCF7L2 mediates two important responses to nicotine in the medial habenula region of the rodent brain: aversion to nicotine, and regulation of blood sugar levels through a polysynaptic habenula–pancreas circuit.
- Alexander Duncan
- , Mary P. Heyer
- & Paul J. Kenny
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Article |
Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis
The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of communication—which is unique to mammals—between thermogenic adipocytes and sympathetic neurons.
- Xing Zeng
- , Mengchen Ye
- & Bruce M. Spiegelman
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Letter |
A wireless closed-loop system for optogenetic peripheral neuromodulation
A closed-loop implantable bioelectronic device that can modulate peripheral neuronal activity is used to improve bladder function in a rat model of cystitis.
- Aaron D. Mickle
- , Sang Min Won
- & John A. Rogers
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Letter |
A TRP channel trio mediates acute noxious heat sensing
Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.
- Ine Vandewauw
- , Katrien De Clercq
- & Thomas Voets
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Letter |
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Group 2 innate lymphoid cells express the neuromedin U receptor 1 (NMUR1) and respond to neuromedin U (NMU) released by adjacent enteric neurons, and this interaction results in an enhanced immediate early response to the nematode Nippostrongylus brasiliensis.
- Vânia Cardoso
- , Julie Chesné
- & Henrique Veiga-Fernandes
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Letter |
The TRPM2 ion channel is required for sensitivity to warmth
The neuronal mechanism for the detection of non-painful warm stimuli has remained unclear; mammalian TRPM2 ion channel is shown to be required for warmth detection in the non-noxious range of 33–38 °C, and surprisingly to mediate responses to warmth in the autonomic nervous system.
- Chun-Hsiang Tan
- & Peter A. McNaughton
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Article |
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Two spider toxins are shown to target the Nav1.1 subtype of sodium channel specifically, shedding light on the role of these channels in mechanical pain signalling.
- Jeremiah D. Osteen
- , Volker Herzig
- & David Julius
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Article |
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
This study shows that nematodes without a germ line re-allocate resources to the soma, resulting in elevated proteasome activity, clearance of damaged proteins and increased longevity; this activity is associated with the increased expression of rpn-6 mediated by the transcription factor DAF-16.
- David Vilchez
- , Ianessa Morantte
- & Andrew Dillin
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Article |
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
Neurons of the peripheral nervous system need survival factors to prevent their death during development. Most in the central nervous system do not. Why are peripheral neurons so needy? Here it is shown that the neurotrophin receptors TrkA and TrkC, expressed at high levels by many peripheral nervous system neurons, behave as dependence receptors: they instruct neurons to die if there is no ligand around. By contrast, TrkB, expressed mainly in the central nervous system, does not signal death in the absence of ligand.
- Vassiliki Nikoletopoulou
- , Heiko Lickert
- & Yves-Alain Barde