Parasite genomics

Letter
17 October 2018 | Open Access

Genome organization and DNA accessibility control antigenic variation in trypanosomes

Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.

Laura S. M. Müller
, Raúl O. Cosentino
& T. Nicolai Siegel

Letter | 26 January 2015

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation

Parasites of the Theileria genus infect cattle and transform their host cells, a transformation that can be reversed by treatment with the drug buparvaquone; here, a Theileria homologue of the peptidyl-prolyl isomerase PIN1 is shown to be secreted into the host cell, where it promotes transformation and can be directly inhibited by buparvaquone.