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| Open AccessStructures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both receptor activation and inhibition.
- Chuan Hong
- , Noel J. Byrne
- & Kaspar Hollenstein
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Article
| Open AccessOrexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
Orexin signaling is provided by diffusely distributed fibers and involved in different brain circuits that orchestrate sleep and wakefulness states. Here, the authors show that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus and exhibit rapid eye movement (REM) sleep-related actions.
- Hui Feng
- , Si-Yi Wen
- & Jun Zhang