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| Open AccessUnraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model
The mechanisms of deep-brain stimulation for psychiatric disorders remain insufficiently understood. Here, the authors identified recruitment of cortico-striatal regions, in particular the medial orbitofrontal cortex, as a mechanism to treat compulsivity.
- Bastijn J. G. van den Boom
- , Alfredo Elhazaz-Fernandez
- & Ingo Willuhn
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Article
| Open AccessCortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
The neurochemical basis of compulsive behaviour is not well understood. Here, the authors show that levels of glutamate and GABA in the supplementary motor area and anterior cingulate cortex relate to compulsive behaviour in healthy controls and individuals with OCD.
- Marjan Biria
- , Paula Banca
- & Trevor W. Robbins
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Article
| Open AccessKetamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice
Intravenous infusion of ketamine rapidly reduces obsessive-compulsive disorder symptoms. Here, the authors show in mice that ketamine acts by increasing activity in a fronto-striatal circuit that causally controls compulsive grooming behaviour.
- Gwynne L. Davis
- , Adelaide R. Minerva
- & Lisa A. Gunaydin
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Article
| Open AccessA unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.
- Ningfei Li
- , Juan Carlos Baldermann
- & Andreas Horn
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Article
| Open AccessDeep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function
Deep brain stimulation (DBS) is a promising treatment for psychiatric disorders, but its mechanism in relieving symptoms is unclear. Here, the authors show that DBS of ventral internal capsule/ventral striatum (VCVS) may act by enhancing prefrontal cortex oscillations that in turn enhance cognitive control.
- A. S. Widge
- , S. Zorowitz
- & D. D. Dougherty
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Article
| Open AccessIntegrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.
- Hyun Ji Noh
- , Ruqi Tang
- & Kerstin Lindblad-Toh