Neuromuscular disease articles within Nature

Featured

  • Article |

    Cytoplasmic, amyloid-like oligomeric assemblies that contain TDP-43 are increased in damaged tissues with elevated regeneration, thereby enhancing the possibility of amyloid fibre formation and/or aggregation of TDP-43 in disease.

    • Thomas O. Vogler
    • , Joshua R. Wheeler
    •  & Roy Parker

  • News & Views |

    A mutant repeating DNA sequence produces a toxic RNA molecule that causes the neuromuscular disorder myotonic dystrophy type 1. An ‘antisense’ therapy that targets this RNA in cell nuclei shows promise in mice. See Letter p.111

    • Peter K. Todd
    •  & Henry L. Paulson

  • Letter |

    Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward for the treatment of muscular dystrophy.

    • Stefan M. Gehrig
    • , Chris van der Poel
    •  & Gordon S. Lynch

  • News & Views |

    A previously unsuspected genetic mechanism underlies a type of muscular dystrophy common in Japan. A therapeutic approach based on this finding and tested in mice has come up with encouraging results. See Letter p.127

    • Masayuki Nakamori
    •  & Charles Thornton

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