Review Article
|
Open Access
Featured
-
-
Article
| Open AccessOxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy
Conventional photodynamic therapy (PDT) is hindered by oxygen-dependent photosensitization pathways and high-power-density photoexcitation. Here, the authors develop polymer-based organic photosensitizers (PSs) through PS skeleton design and side-chain engineering to allow tumor-specific PDT under oxygen-free conditions using ultralow-power 808 nm photoexcitation.
- Yufu Tang
- , Yuanyuan Li
- & Bin Liu
-
Article
| Open AccessMesoporous nanoperforators as membranolytic agents via nano- and molecular-scale multi-patterning
Plasma membrane lysis is an effective anticancer strategy that mostly relies on soluble molecular membranolytic agents, while nanomaterial-based membranolytic agents have been unexplored. Herein, the authors report a nano- and molecular-scale multi-patterning strategy for fabricating mesoporous membranolytic nanoperforators with an intrinsic membranolytic activity.
- Yannan Yang
- , Shiwei Chen
- & Chengzhong Yu
-
Article
| Open AccessUltrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy
Emulating the killing function of neutrophils, which involves the enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), is promising for cancer therapy, but developing SOD-MPO cascade in one nanozyme is challenging. Here the authors report ultrasmall AuPd alloy nanozymes that mimic neutrophil enzymatic cascades for catalytic treatment of tumors.
- Xiangqin Meng
- , Huizhen Fan
- & Kelong Fan
-
Article
| Open AccessNanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Lung cancer is characterized by an immunosuppressive microenvironment, limiting responses to immunotherapies. Here the authors report the design of a pH-responsive nanomedicine for the co-delivery of a T-type calcium channel inhibitor and of a small molecule targeting CD47, promoting anti-tumor immune responses in orthotopic lung cancer preclinical models.
- Yuedong Guo
- , Qunqun Bao
- & Jianlin Shi
-
Article
| Open AccessSphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
Epacadostat is a selective IDO1 inhibitor shown to promote anti-tumor immune responses in preclinical models, however it has failed in a Phase III clinical trial for treating metastatic melanoma. Here the authors design a sphingomyelin-derived nanovesicle system for epacadostat delivery with improved pharmacokinetics and anti-tumor activity when combined with a PD-1 inhibitor in melanoma preclinical models.
- Zhiren Wang
- , Wenpan Li
- & Jianqin Lu
-
Article
| Open AccessNanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here the authors use tin monosulfide nanoparticles as nano-sonosensitizers to overcome the stromal barrier in triple negative breast cancer and improve the efficacy of sonodynamic therapy and boost antitumor immunity.
- Yongjiang Li
- , Wei Chen
- & Wei Tao
-
Article
| Open AccessAdaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
There is an emerging interest in the use of mRNA therapeutics in cancer treatment, but their precise in vivo delivery remains a challenge. Here the authors develop IFN-γ mRNA-loaded small extracellular vesicles (sEVs) with CD64 overexpressed on their surface and demonstrate its efficacy in glioblastoma mouse models resistant to immunotherapy.
- Shiyan Dong
- , Xuan Liu
- & Wen Jiang
-
Article
| Open AccessCell microparticles loaded with tumor antigen and resiquimod reprogram tumor-associated macrophages and promote stem-like CD8+ T cells to boost anti-PD-1 therapy
Tumor associated macrophages (TAMs) contribute to the immunosuppressive tumor microenvironment, including hepatocellular carcinoma (HCC). Here the authors show that macrophage-derived microparticles modified with a M2-like macrophage targeting peptide and loaded with the TLR7/8 agonist resiquimod reprogram TAMs from immunosuppressive to inflammatory, promoting anti-tumor immune responses in preclinical HCC models.
- Xiaoqiong Zhang
- , Zhaohan Wei
- & Lu Gan
-
Article
| Open AccessBiosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation
Bacteria have been exploited as a potential bio-factory for the synthesis of nanoparticles. Here the authors report the generation of gold nanoparticles from Escherichia coli and show their application for eliciting hyperthermia and anti-tumor immune responses in preclinical cancer models.
- Hao Qin
- , Yang Chen
- & Ruifang Zhao
-
Article
| Open AccessCholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy
Strategies for biological membrane engineering have been proposed to enhance their anti-clearance efficiency and improve their clinical translation potential. Here the authors design nanoparticles coated with low-cholesterol membranes from T cells overexpressing PD1, showing reduced clearance in the blood and improved anti-tumor efficacy when loaded with a STING agonist and a photothermal agent.
- Lin Li
- , Mengxing Zhang
- & Ling Zhang
-
Article
| Open AccessPrussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments
Chemodynamic therapy (CDT) uses Fenton chemistry to covert hydrogen peroxide in cancer cells to toxic hydroxyl radicals, but endogenous hydrogen peroxide is insufficient to drive sustainable CDT. Here, the authors report a water oxidation CoFe Prussian blue nanoframe to provide sustained, external energy free self-supply of hydroxyl radicals for CDT.
- Liu-Chun Wang
- , Pei-Yu Chiou
- & Chen-Sheng Yeh
-
Article
| Open AccessPhotothermia at the nanoscale induces ferroptosis via nanoparticle degradation
Iron oxide magnetic nanoparticles are utilized in Fe(II)-induced ferroptosis for cancer therapy, but controlling the Fe(II) release from magnetic nanoparticles remains challenging. Here the authors reveal that photothermia at the nanoscale can remotely trigger the degradation of magnetic nanoparticles, leading to Fe(II) release and a synergistic photothermo-ferroptotic therapy.
- Alexandre Fromain
- , Jose Efrain Perez
- & Claire Wilhelm
-
Article
| Open AccessGeneration of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation
Whole autologous tumor cell vaccine (TCV) has been proposed as a tool for cancer immunotherapy. Here the authors describe the design of a TCV platform based on photothermal nanoparticle-loaded tumor cells, triggering NIR laser irradiation induced anti-tumor immune responses at the vaccination site.
- Jiaqi Meng
- , Yanlin Lv
- & Wei Wei
-
Article
| Open AccessNanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy
Targeting the TGF-β signaling pathway has been exploited to relieve immunosuppression in the tumor microenvironment. Here the authors describe the design of a nanoplatform integrating the TGF-β receptor 1 inhibitor LY2157299 and the ROS-responsive JQ1 pro-drug, promoting anti-tumor immune responses in preclinical cancer models.
- Mengxue Zhou
- , Jiaxin Wang
- & Haijun Yu
-
Article
| Open AccessGas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation
Gas-based therapy is an emerging therapeutic option for cancer treatment. Here the authors design a virus-mimicking hollow mesoporous tetrasulfide-doped organosilica for co-encapsulation of an aggregation-induced emission (AIE)-active luminogen and manganese carbonyl to fabricate a STING activating gas nano-adjuvant for photo-immunotherapy, promoting anti-tumor immune response in preclinical models.
- Kaiyuan Wang
- , Yang Li
- & Xiaoyuan Chen
-
Article
| Open AccessModular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field
Several strategies have been employed to enhance the tumor-targeting and anti-cancer properties of engineered bacteria. Here the authors describe the design of alternating magnetic field-manipulated bacteria engineered to release an anti-CD47 nanobody, promoting anti-tumor immune response in preclinical cancer models.
- Xiaotu Ma
- , Xiaolong Liang
- & Guangjun Nie
-
Article
| Open AccessMechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels
Nanomedicine proofed to be efficient in cancer therapy but rapid clearance from blood circulation by reticuloendothelial system (RES) severely limits the antitumor efficacy. Here, the authors design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES.
- Zheng Li
- , Yabo Zhu
- & Zifu Li
-
Article
| Open AccessMagnesium hexacyanoferrate nanocatalysts attenuate chemodrug-induced cardiotoxicity through an anti-apoptosis mechanism driven by modulation of ferrous iron
Doxorubicin is commonly used in cancer chemotherapy, but its cardiotoxicity from iron overload is one of the severe side effects. Here, the authors prepare magnesium hexacyanoferrate nanocatalysts to capture excess ferrous species and eliminate cytotoxic radical species in vitro and in vivo.
- Minfeng Huo
- , Zhimin Tang
- & Jianlin Shi
-
Article
| Open AccessAtomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy
Single-atom catalysts emerge as nanocatalytic medicine in chemodynamic therapy but suffer from inefficient kinetics for the production of reactive oxygen species because of the cell’s antioxidative mechanisms. Here, the authors employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatment.
- Liu-Chun Wang
- , Li-Chan Chang
- & Chen-Sheng Yeh
-
Article
| Open AccessA nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance
One of the mechanisms underlying platinum (Pt) resistance is the spontaneous nucleotide-excision repair of cancer cells. Here, nuclease-mimetic Pt nanozymes are targeted to the cancer cell nucleus and induce concurrent DNA platination and oxidative cleavage to overcome Pt resistance.
- Fangyuan Li
- , Heng Sun
- & Daishun Ling
-
Article
| Open AccessFlash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment
Achieving the delivery of drugs into the centre of solid tumours is a challenge due to the tumour micro-environment. Here, the authors propose a system for using the rapid release of large quantities of drug inside tumour microcapillaries for the gradient-driven diffusion of drugs into solid tumours.
- Ivan V. Zelepukin
- , Olga Yu. Griaznova
- & Andrei V. Zvyagin
-
Article
| Open AccessSystematic design of cell membrane coating to improve tumor targeting of nanoparticles
Surface modification of nanoparticles by cell membrane (CM) coating to improve their bio-interface properties often results in partial coating. Here the authors show that partial coating is an intermediate state due to the absorption of CM fragments or vesicles and can be resolved by increasing CM fluidity with external phospholipids.
- Lizhi Liu
- , Dingyi Pan
- & Vesa-Pekka Lehto
-
Article
| Open AccessBiomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia
Metal organic frameworks (MOF) coated with mammalian cell membranes have good biocompatibility. Here, the authors develop a cobalt based hydrogen sulphide producing MOF cloaked with a macrophage membrane and show that the subsequent system can reduce tumour growth in mice.
- Kai Cheng
- , Bo Liu
- & Yuan-Di Zhao
-
Article
| Open AccessCancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages
Tumor-associated macrophages are mostly pro-tumorigenic, due to their re-programming by the tumor microenvironment. Here authors show that nanoliposomes, incorporating phospholipids with a flipping-tail chain, are engulfed specifically by intratumoral, alternatively activated macrophages, while delivering a cargo that converts these cells into anti-tumor macrophages.
- Praneeth R. Kuninty
- , Karin Binnemars-Postma
- & Jai Prakash
-
Article
| Open AccessCatalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy
Ultrasound-based therapies in combination with immune checkpoint blockade have been shown to improve the efficacy of cancer immunotherapy. Here the authors report the design of a pH-responsive and sono-irradiation activatable nanosystem functionalized with anti-PD-L1 and adenosine deaminase for sono-metabolic cancer immunotherapy.
- Chi Zhang
- , Jingsheng Huang
- & Kanyi Pu
-
Article
| Open AccessCatalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy
Nanoparticles have recently received attention in radiation therapy since they can act as radioenhancers. In this article, the authors report on the dose enhancement capabilities of a series of nanoparticles based on their metal core composition and beam characteristics, obtaining designing criteria for their optimal performance in specific radiotreatments.
- Lukas R. H. Gerken
- , Alexander Gogos
- & Inge K. Herrmann
-
Article
| Open AccessCombining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy
The p53 tumor suppressor gene is frequently mutated in liver cancer. Here the authors show that restoration of p53 expression with a mRNA nanoparticle platform elicits anti-tumor immune responses and promotes response to immune checkpoint blockade in preclinical models of p53-null hepatocellular carcinoma.
- Yuling Xiao
- , Jiang Chen
- & Jinjun Shi
-
Article
| Open AccessDegradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics
The properties of mesoporous nanomaterials have been exploited for several applications, including drug delivery and NIR-II photoacoustic imaging. Here, the authors design monodispersed semimetallic mesoporous antimony nanospheres with photothermal conversion efficiency in the second near-infrared range and drug loading capacity, showing their potential for cancer photothermal/chemo therapy.
- Yu Chen
- , Zhongzheng Yu
- & Junle Qu
-
Article
| Open AccessInterfacial-confined coordination to single-atom nanotherapeutics
Developing single atom systems with improved catalytic potential for bio-application has major therapeutic potential. Here, the authors report on the development of a metal single-atom on a carbon dot support confined within mesoporous silica for the development of therapeutic agents.
- Limei Qin
- , Jie Gan
- & Jianlin Shi
-
Article
| Open AccessCell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles
Cell membrane coating of nanomaterials has become an attractive method of improving targeting, residence and biocompatibility. Here, the authors demonstrated that most nanoparticles are only partially coated by standard methods, and show the coating degree can impact the biological fate of nanoparticles.
- Lizhi Liu
- , Xuan Bai
- & Vesa-Pekka Lehto
-
Article
| Open AccessPeroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy
The control of reactive oxygen species in cancer cells is an attractive approach for anticancer applications. Here, the authors create a peroxisome inspired lactate oxidase and catalase loaded hydrogel with iron nanoparticles and NIR photosensitizer for glutathione activated chemodynamic and photodynamic therapy.
- Xing Qin
- , Chu Wu
- & Yongsheng Li
-
Article
| Open AccessIntratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination
Iron gall chelate (GA-Fe) can promote oxygen reduction reactions and reactive oxygen species generation which causes chemical corrosion. Here, the authors, inspired by this phenomenon, develop a composite nanomedicine for tumour therapy constructed by loading gallate into Fe-engineered and PEGylated mesoporous silica nanocarrier, and show that it inhibits tumour growth.
- Bowen Yang
- , Heliang Yao
- & Jianlin Shi
-
Article
| Open AccessSemiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy.
- Chi Zhang
- , Ziling Zeng
- & Kanyi Pu
-
Article
| Open AccessQuantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy
Quantification of intratumoral nanoparticles internalisation in vivo is crucial but challenging. Here, the authors develop a binary ratiometric nanoreporter that can quantify internalisation and predict nanotherapeutic responses based on intracellular nanoparticle exposure.
- Qingqing Yin
- , Anni Pan
- & Yiguang Wang
-
Article
| Open AccessBioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes anti-tumor immune responses in preclinical cancer models.
- Keman Cheng
- , Ruifang Zhao
- & Guangjun Nie
-
Article
| Open AccessPhotoactivated nanomotors via aggregation induced emission for enhanced phototherapy
Induced motion has emerged as a method to increase the efficacy of delivery and therapeutic outcomes using nanomaterials. Here, the authors report on a Janus gold shell polymersome with aggregation-induced emission molecules for phototactic and photodynamic therapy applications.
- Shoupeng Cao
- , Jingxin Shao
- & Jan C. M. van Hest
-
Article
| Open AccessImmunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy
Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.
- Cheng-Tao Jiang
- , Kai-Ge Chen
- & Jun Wang
-
Article
| Open AccessActivatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer
Precise control of immune response remains challenging for cancer immunotherapy. Here, the authors report on photothermally activatable semiconducting polymeric pro-agonist in response to second near-infrared window light for regulated photothermal immunotherapy.
- Yuyan Jiang
- , Jiaguo Huang
- & Kanyi Pu
-
Article
| Open AccessA hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy
Tumor hypoxia is a major limitation in radiotherapy, and strategies to address this often fail due to high oxygen consumption. Here, the authors report a nanomaterial assembly for the simultaneous reduction in mitochondrial respiration and to supply oxygen to potentiate radiotherapy.
- Wei Tang
- , Zhen Yang
- & Xiaoyuan Chen
-
Review Article
| Open AccessEngineering microrobots for targeted cancer therapies from a medical perspective
Microbot delivery devices are the latest development in attempts to overcome the systemic toxicity associated with classical chemotherapy. Here, the authors review the recent progress in the field with a focus on the clinical translation and potential of the research and give a future perspective on this topic.
- Christine K. Schmidt
- , Mariana Medina-Sánchez
- & Oliver G. Schmidt
-
Article
| Open AccessTargeted scavenging of extracellular ROS relieves suppressive immunogenic cell death
Reactive oxygen species in the tumour microenvironment can have an immunosuppressive effect. Here, the authors devise a nanoparticle that anchors to the extracellular matrix within tumours and scavenges reactive oxygen species, resulting in an enhanced immune response within the tumour.
- Hongzhang Deng
- , Weijing Yang
- & Xiaoyuan Chen
-
Article
| Open AccessHybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.
- Lang Rao
- , Lei Wu
- & Xiaoyuan Chen
-
Article
| Open AccessIntratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
Intracellular generation of gold nanoparticles has drawn attention but toxic effects have limited potential applications. Here, the authors report on the delivery of ionic gold with PEG resulting in faster synthesis and reduced toxicity due to lower concentrations of ionic gold required and explore potential applications.
- Aaron S. Schwartz-Duval
- , Christian J. Konopka
- & Dipanjan Pan
-
Article
| Open AccessPhotothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
Cancer stem cells (CSCs) are known to induce chemotherapy resistance, and cause tumour relapse and metastasis. Here, the authors develop photoactive nanocarbon complexes with second near-infrared photothermal ability to target cancer cells overexpressing the receptor TRPV2 and show it to suppress CSCs through dysregulation of the Wnt/β-catenin signalling pathway.
- Yue Yu
- , Xi Yang
- & Eijiro Miyako
-
Article
| Open AccessTransformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy
Due to tumour microenvironment, Fenton reactions have low therapeutic efficiency. Here the authors report on the application of NIR-II hybrid semiconducting nanozymes for combined photothermal therapy and enhanced ferrotherapy with photoacoustic imaging and show application in vivo in tumour models.
- Yuyan Jiang
- , Xuhui Zhao
- & Ruiping Zhang
-
Article
| Open AccessChemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy
The presence of several biological barriers impede the efficacy of nano-mediated drug delivery for solid cancer therapy. Here, the authors develop a nano-pathogenoid system that targets circulating neutrophils and show that it overcomes these biological barriers and improves tumour targeting and efficacy.
- Min Li
- , Shuya Li
- & Yucai Wang
-
Article
| Open AccessSelf-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.
- Dongdong Wang
- , Huihui Wu
- & Yanli Zhao
-
Article
| Open AccessCheckpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.
- Wenwen Yue
- , Liang Chen
- & Yu Chen
-
Article
| Open AccessEstablishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
Nanoparticle applications are limited by insufficient understanding of physiochemical properties on in vivo disposition. Here, the authors explore the influence of size, surface chemistry and administration on the biodisposition of mesoporous silica nanoparticles using image-based pharmacokinetics.
- Prashant Dogra
- , Natalie L. Adolphi
- & C. Jeffrey Brinker