Featured
-
-
Article
| Open AccessThe gut ileal mucosal virome is disturbed in patients with Crohn’s disease and exacerbates intestinal inflammation in mice
Gut bacteriome dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Here, they authors characterize the small bowel (terminal ileum) virome and bacteriome of patients with Crohn´s Disease (CD), and show that ileal virions from CD patients causally exacerbate intestinal inflammation in IBD mouse models.
- Zhirui Cao
- , Dejun Fan
- & Tao Zuo
-
Article
| Open AccessMucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease
Here, through parallel profiling of the mucosal transcriptome and microbiome of intestinal biopsies derived from patients with IBD and from non-IBD controls, the authors characterize interactions between gene expression and microbiota composition associated with traits of patients with inflammatory bowel diseases. Peer Review Information: Nature Communications thanks Robert Häsler, and the other, anonymous, reviewers for their contribution to the peer review of this work. A peer review file is available.
- Shixian Hu
- , Arno R. Bourgonje
- & Rinse K. Weersma
-
Article
| Open AccessIgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency
IgA protects mucosal barriers by coating microorganisms, yet infection related complications are rare in human IgA deficiency. Authors here show that in humans lacking IgA, IgG assists IgM in coating of most bacterial families, thus contributing to gut mucosal defence.
- Carsten Eriksen
- , Janne Marie Moll
- & Susanne Brix
-
Article
| Open AccessParabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
Here, the authors show that the gut commensal Parabacteroides distasonis alleviates insulin resistance via nicotinic acid-intestinal GPR109a axis activation, a process promoted by Dendrobium officinale polysaccharide.
- Yonggan Sun
- , Qixing Nie
- & Shaoping Nie
-
Article
| Open AccessThe interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis
Here, Schoeler et al. investigate how interaction between dietary lipids and the gut microbiota affect hepatic steatosis and host metabolism, showing that dietary lipids impact the gut microbiota composition independent on fiber intake in humans and mice.
- Marc Schoeler
- , Sandrine Ellero-Simatos
- & Robert Caesar
-
Comment
| Open AccessA gut feeling for drugs that have metabolic benefits
Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors. Pang and colleagues reported that REV intervention (REV-I) alters gut microbiota and bile acid profile, leading to the inhibition of farnesoid X receptor (FXR) and attenuation of scavenger receptor class B type 1 (SR-B1)-mediated chylomicron secretion. This highlights a therapeutic potential of targeting gut microbiome and intestinal SR-B1 for obesity and diabetes treatment.
- Eryun Zhang
- , Alon Agua
- & Wendong Huang
-
Article
| Open AccessMicrobiota alters the metabolome in an age- and sex- dependent manner in mice
Commensal microbes contribute considerably to mammalian metabolism. Here the authors report the relative contributions of microbiome, age and sex to metabolism throughout the body and uncover age- and sex- specificity in how microbes affect metabolite levels in mice.
- Kirsty Brown
- , Carolyn A. Thomson
- & Kathy D. McCoy
-
Article
| Open AccessIdentifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting
Dietary glycans are a major driver of the human gut microbiota composition. Here, the authors apply next-generation metabolic labeling coupled with fluorescence-activated cell sorting to identify and isolate gut bacteria consumers of dietary glycans in human stool samples, linking bacteria to the glycans they consume.
- Lharbi Dridi
- , Fernando Altamura
- & Bastien Castagner
-
Article
| Open AccessReduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice
Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool samples collected in the trial to report that this phenotype is transmissible via microbial transfer to germ free mice, as assessed by reduced ethanol acceptance, intake and preference.
- Jennifer T. Wolstenholme
- , Justin M. Saunders
- & Jasmohan S. Bajaj
-
Article
| Open AccessMachine learning aided construction of the quorum sensing communication network for human gut microbiota
Microbes communicate with each other by Quorum sensing (QS) languages. Here the authors construct a QS database and the QS communication network to decipher intricate QSbased communications and form one of the key knowledge maps for human gut microbiota.
- Shengbo Wu
- , Jie Feng
- & Jianjun Qiao
-
Article
| Open AccessTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties. Here, Huang et al. show that this is mostly due to the action of a pigment in Pu-erh tea that induces changes in certain gut microbiota and bile acid levels, thus modulating the gut-liver metabolic axis.
- Fengjie Huang
- , Xiaojiao Zheng
- & Wei Jia
-
Article
| Open AccessColonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation
In a large prospective cohort of liver transplantation (LT) recipients, the authors identify associations between colonization by multidrug-resistant bacteria (MDRB) and microbiome dysbiosis pre- and post-LT, suggesting colonizing MDRB as an important target for microbiome-informed therapeutic approaches post-LT.
- Medini K. Annavajhala
- , Angela Gomez-Simmonds
- & Anne-Catrin Uhlemann
-
Article
| Open AccessActive thrombin produced by the intestinal epithelium controls mucosal biofilms
The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.
- Jean-Paul Motta
- , Alexandre Denadai-Souza
- & Nathalie Vergnolle
-
Article
| Open AccessThe gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
The role of the gut microbiota in hepatic lipid metabolism is controversial and incompletely understood. Here the authors perform multi-omics analyses of altered lipid metabolic processes in germ-free and specific pathogen-free mice, revealing how the gut microbiota affects hepatic fatty acid desaturation and elongation.
- Alida Kindt
- , Gerhard Liebisch
- & Josef Ecker
-
Review Article
| Open AccessMicrobial tryptophan catabolites in health and disease
Gut microbial metabolites are known to impact many physiological processes of the host and play a critical role in immune-homeostasis. Here the authors review our current understanding and appreciation of the importance of microbially derived tryptophan catabolites during both health and disease.
- Henrik M. Roager
- & Tine R. Licht
-
Article
| Open AccessDelayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation
Gut microbial dysbiosis in infancy is associated with childhood atopy and the development of asthma. Here, the authors show that gut microbiota perturbation is evident in the very earliest stages of postnatal life, continues throughout infancy, and can be partially rescued by Lactobacillus supplementation in high-risk for asthma infants.
- Juliana Durack
- , Nikole E. Kimes
- & Susan V. Lynch
-
Article
| Open AccessShort-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
Short-chain fatty acids (SCFA) are a main class of metabolites derived from fermentation of dietary fibre in the intestine. Here, the authors show that dietary administration of SCFA is associated with inhibition of osteoclast differentiation, increased bone mass, and reduced pathological bone loss in mice.
- Sébastien Lucas
- , Yasunori Omata
- & Mario M. Zaiss
-
Article
| Open AccessGastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.
- Cristina Llorente
- , Peter Jepsen
- & Bernd Schnabl
-
Article
| Open AccessAkkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.
- Renee L. Greer
- , Xiaoxi Dong
- & Natalia Shulzhenko
-
Article
| Open AccessA single gene of a commensal microbe affects host susceptibility to enteric infection
The interactions between gut bacteria and enteric pathogens are poorly understood. Here, Yoon et al. show that subinhibitory antibiotic treatment in a mouse model leads to overgrowth of an E. coli strain carrying a catalase-encoding gene that enhances infection with the human pathogen Vibrio cholerae.
- Mi Young Yoon
- , Kyung Bae Min
- & Sang Sun Yoon
-
Article
| Open AccessAntibiotics in neonatal life increase murine susceptibility to experimental psoriasis
Commensal microbes are necessary for proper development of the immune system. Here Zanvit et al. show that neonatal antibiotics treatment causes long-term changes in the gut and skin microbiomes, and exacerbates immune-mediated skin pathology at adult age in mouse experimental models of psoriasis.
- Peter Zanvit
- , Joanne E. Konkel
- & WanJun Chen
-
Article
| Open AccessBile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Gastric bypass surgery is one of the most effective interventions to achieve durable weight loss. Here, Flynnet al. show that, in mice, bile diversion to the small intestine results in beneficial and sustained metabolic improvements similar to Roux-en-Y gastric bypass surgery.
- Charles Robb Flynn
- , Vance L. Albaugh
- & Naji N. Abumrad
-
Article
| Open AccessMetabolic and metagenomic outcomes from early-life pulsed antibiotic treatment
The potential recovery of the human gut microbiota after an antibiotic treatment, and its effects on our health, are poorly understood. Here, the authors use a mouse model mimicking paediatric antibiotic use to shed new light into these processes.
- Yael R. Nobel
- , Laura M. Cox
- & Martin J. Blaser
-
Article
| Open AccessGanoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
Ganoderma lucidumis a medicinal mushroom used in Traditional Chinese Medicine with putative anti-diabetic properties. Here, the authors show that polysaccharides from a water extract of this mushroom exert beneficial metabolic effects by modulating the composition of the gut microbiota in mice.
- Chih-Jung Chang
- , Chuan-Sheng Lin
- & Hsin-Chih Lai
-
Article |
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
Growing evidence suggests that environmental rather than genetic factors are major contributors to asthma development. Here the authors show that high intake of dietary fibre by pregnant mice increases resistance of their progeny to the development of allergic airways disease.
- Alison N. Thorburn
- , Craig I. McKenzie
- & Charles R. Mackay
-
Article
| Open AccessAdipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
Endocannabinoids are bioactive lipid molecules produced in the body. Here, Geurts et al. create mice lacking the endocannabinoid-producing enzyme NAPE-PLD in adipocytes and report defects in adipose-induced browning, which are mediated by alterations in the gut microbiome.
- Lucie Geurts
- , Amandine Everard
- & Patrice D. Cani
-
Article
| Open AccessAntibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
The gut microbiota of malaria-transmitting mosquitoes contributes to the insects’ resistance to the parasite. Here, Gendrin et al. show that antibiotics in ingested human blood alter the mosquito gut microbiota and increase the insect’s survival, fecundity and susceptibility to the parasites.
- Mathilde Gendrin
- , Faye H. Rodgers
- & George K. Christophides
-
Article
| Open AccessIntestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
Gut microbes are known to influence whole-body metabolism. Here Everard et al.show the adaptor protein MyD88 in intestinal epithelial cells is sensitive to changes in the diet and affects composition of the gut microbiota, which influences the development of obesity and associated diseases.
- Amandine Everard
- , Lucie Geurts
- & Patrice D. Cani
-
Article |
Prediction and quantification of bioactive microbiota metabolites in the mouse gut
Metabolites produced by the gut microbiota can potentially affect our physiology. Here, the authors present a metabolomics strategy that models microbiota metabolism as a reaction network and uses pathway analysis to facilitate identification and characterization of microbial metabolites.
- Gautham V. Sridharan
- , Kyungoh Choi
- & Arul Jayaraman
-
Article |
Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer
Abundance of certain gut enterobacteria is correlated with inflammation and cancer development in humans, but the interplay between the three factors is unclear. Here the authors show that gut inflammation is required for bacteria-associated tumour development in mouse models.
- Janelle C. Arthur
- , Raad Z. Gharaibeh
- & Christian Jobin
-
Article |
Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria
Research on the roles played by gut microbes in human health is hampered by our inability to isolate and study them in pure cultures. Here, the authors describe an approach that allows targeted cultivation and rapid characterization of a significant proportion of human gut bacteria.
- Elizabeth A. Rettedal
- , Heidi Gumpert
- & Morten O.A. Sommer
-
Article
| Open AccessIndividual diet has sex-dependent effects on vertebrate gut microbiota
Diet variations can alter gut microbial composition, but the potential influence of host genetic factors on these effects is unclear. Here, the authors show, in humans and in natural and laboratory fish populations, that such effects are dependent on the host’s sex, a genetically determined factor.
- Daniel I. Bolnick
- , Lisa K. Snowberg
- & Richard Svanbäck
-
Article |
An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling
Polysaccharide A (PSA) from the human intestinal commensal Bacteroides fragilis mediates protection against the experimental autoimmune encephalomyelitis in mice. Here, Wang et al. show that the protective function of PSA is exerted through its action on CD39+regulatory CD4 T cells via Toll-like receptor 2 signalling.
- Yan Wang
- , Kiel M. Telesford
- & Lloyd H. Kasper
-
Article
| Open AccessTipping elements in the human intestinal ecosystem
Intestinal microbes can have important effects on our health. Here, the authors analyse the gut microbiota composition in 1,000 western adults and find that certain bacteria are either abundant or nearly absent, and that these alternative states are associated with ageing and overweight.
- Leo Lahti
- , Jarkko Salojärvi
- & Willem M. de Vos
-
Article |
High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model
The influence of diet on the establishment of gut microbiota early in life is poorly understood. Here the authors show, in a primate model, that maternal diet during pregnancy affects the offspring’s microbiome, and that dietary intervention after weaning only partially reverses this effect.
- Jun Ma
- , Amanda L. Prince
- & Kjersti M. Aagaard
-
Article
| Open AccessGut microbiome of the Hadza hunter-gatherers
Gut microbes influence our health and may contribute to human adaptation to different lifestyles. Here, the authors describe the gut microbiome of a community of hunter-gatherers and identify unique features that could be linked to a foraging lifestyle.
- Stephanie L. Schnorr
- , Marco Candela
- & Alyssa N. Crittenden
-
Article |
Generation of colonic IgA-secreting cells in the caecal patch
Gut-associated Peyer’s patches are lymphoid tissues that generate IgA-secreting cells, however less is known about related caecal patches. Here, Masahata et al.show that caecal patches produce IgA-positive B cells that migrate to the intestines to maintain faecal microbiota homeostasis.
- Kazunori Masahata
- , Eiji Umemoto
- & Kiyoshi Takeda
-
Article |
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Antibiotics alter the intestinal microbiota and facilitate colonization of pathogens such as Clostridium difficile. Here, the authors show that antibiotic-induced shifts in the mouse gut microbiome are correlated with changes in levels of certain metabolites that C. difficilecan use for germination and growth.
- Casey M. Theriot
- , Mark J. Koenigsknecht
- & Vincent B. Young
-
Article
| Open AccessGenome-wide mapping of gene–microbiota interactions in susceptibility to autoimmune skin blistering
The pathogenesis of inflammatory disorders afflicting the skin is multifactorial. Srinivas et al. show that diversity of the skin microbiota is a critical factor determining the susceptibility to epidermolysis bullosa acquisita, a chronic mucocutaneous autoimmune skin blistering disease.
- Girish Srinivas
- , Steffen Möller
- & Saleh M. Ibrahim
-
Article
| Open AccessGenome signature-based dissection of human gut metagenomes to extract subliminal viral sequences
Bacteriophages have a significant impact on microbial ecosystems, but additional tools are needed to assess viral communities. Ogilvie et al.present a new strategy to extract viral sequences from metagenomic data sets, and present new insights on their function in the gut ecosystem.
- Lesley A. Ogilvie
- , Lucas D. Bowler
- & Brian V. Jones
-
Article
| Open AccessHuman gut microbiota community structures in urban and rural populations in Russia
The structure of the human gut microbiota has been shown to vary between populations. Tyakht et al.analyse the gut microbiota assembly from Russian individuals living in urban and rural areas, and compare these with previously studied populations.
- Alexander V. Tyakht
- , Elena S. Kostryukova
- & Vadim M. Govorun
-
Article |
Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
The appearance of antibiotic resistance has been attributed to the misuse of antibiotics. By analysing the diversity of antibiotic resistance genes present in 162 human gut microbiota samples, the authors find that Chinese individuals harbour a larger pool of resistance genes than Spanish or Danish counterparts.
- Yongfei Hu
- , Xi Yang
- & Baoli Zhu
-
Article
| Open AccessStructural modulation of gut microbiota in life-long calorie-restricted mice
Calorie restriction has been shown to extend lifespan in diverse model systems, however, the mechanisms underlying this effect remain unclear. Zhang et al.show that calorie restriction changes the structure of the gut microbiota in mice, enriching for phylotypes positively correlated with lifespan.
- Chenhong Zhang
- , Shoufeng Li
- & Liping Zhao
-
Article
| Open AccessThe gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
The gut microbiota produces metabolites such as short-chain fatty acids (SCFAs), which can influence the development of obesity. Here Kimura et al.show that SCFAs act via the receptor GPR43, which acts as a sensor for excessive dietary energy and controls body energy utilization as well as metabolic homoeostasis.
- Ikuo Kimura
- , Kentaro Ozawa
- & Gozoh Tsujimoto
-
Article |
Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice
Epithelial cells in the colon mainly use microbial fermentation products as energy sources. Here Okada et al. find that lactate produced by commensal Lactobacillus murinusregulates colonic epithelial cell proliferation and show that mice are more susceptible to carcinogens when refed after a period of starvation.
- Toshihiko Okada
- , Shinji Fukuda
- & Taeko Dohi
-
Article |
Chimpanzees and humans harbour compositionally similar gut enterotypes
Humans tend to adopt one of a limited number of different bacterial community structures in the gut, known as enterotypes. Moeller et al.now show that these microbial fingerprints are conserved in chimpanzees, and that individuals can switch between enterotypes over periods of several years.
- Andrew H. Moeller
- , Patrick H. Degnan
- & Howard Ochman
-
Article
| Open AccessProstaglandin E2 and SOCS1 have a role in intestinal immune tolerance
The gut is populated by a myriad of microorganisms and how the immune system tolerates their presence is of great interest. Here, by studying colon morphology in multiple knockout mice, the authors demonstrate a potential role for prostaglandin E2 and SOCS1 in mediating immune tolerance.
- Takatoshi Chinen
- , Kyoko Komai
- & Akihiko Yoshimura