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Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
Mycobacterium tuberculosisis intrinsically resistant to most antibiotics. Here, the authors show that the pathogen’s tolerance to three antibiotics, each one targeting a distinct cellular process, is mediated by an antioxidant response that requires the activation of isocitrate lyases.
- Madhumitha Nandakumar
- , Carl Nathan
- & Kyu Y. Rhee
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High specificity in plant leaf metabolic responses to arbuscular mycorrhiza
Plant species share a core metabolome, however the extent to which metabolic responses to environmental cues are also conserved remains unclear. Schweiger et al.describe shifts in the leaf metabolomes of five plant species during mycorrhizal fungal infection, and uncover high species-specificity.
- Rabea Schweiger
- , Markus C. Baier
- & Caroline Müller
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| Open AccessMetabolome-based genome-wide association study of maize kernel leads to novel biochemical insights
Plants produce a variety of metabolites that have a critical role in growth and development. Here, the authors carry out a genome-wide association analysis of metabolites and metabolite features in maize and identify candidate genes involved in secondary metabolism, and a potential biomarker for the genetic improvement of the crop.
- Weiwei Wen
- , Dong Li
- & Jianbing Yan
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Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library
Metabolism is altered in many diseases, and monitoring metabolic changes during treatment could facilitate investigations into treatment efficacy and cellular responses. This study reports an NMR-based method to screen the metabolic responses of mammalian cells to drugs.
- Stefano Tiziani
- , Yunyi Kang
- & Giovanni Paternostro
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Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
The integration of microarray and metabolite data is important for understanding the physiology of model organisms. This study demonstrates how the integration of these kinds of data can provide novel insights into the growth and protein metabolism of two different yeast strains.
- André B. Canelas
- , Nicola Harrison
- & Jens Nielsen