Featured
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Review Article |
Tuberculous meningitis
Tuberculous menigitis (TBM) presents a major health burden around the world, especially in individuals with concomitant HIV infection, in whom mortality is nearly 50%. Here, members of the TBM International Research Consortium summarize our current understanding of TBM pathogenesis, diagnosis and management, and discuss key avenues for future research.
- Robert J. Wilkinson
- , Ursula Rohlwink
- & Guy E. Thwaites
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Year in Review |
2016, the year of Zika virus
In 2016, the literature on neurological infections was, understandably, dominated by Zika virus. However, we should not overlook important publications on the treatment of cryptococcal and bacterial meningitis.
- Diederik van de Beek
- & Matthijs C. Brouwer
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News & Views |
Major advances against a moving target of CNS infections
CNS infections have severe manifestations, often leading to high mortality, but the CNS is usually not the primary target of pathogens, leaving a window of opportunity to prevent neuroinvasion. We must prioritize development of therapies to prevent neurological sequelae that cause long-lasting morbidity and disease burden on society.
- Lisa F. P. Ng
- & Tom Solomon
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Research Highlight |
Uncovering the secrets of the 'brain drain'—the CNS lymphatic system is finally revealed
- Heather Wood
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Research Highlight |
Conjugate vaccine is effective against serogroup A meningococcal meningitis
- Ellen Bible
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News & Views |
Childhood meningitis may be preventable if we can afford it
Bacterial meningitis, one of the infections most feared by parents, and on the mind of every pediatrician who evaluates a febrile child, is an important cause of morbidity and mortality in childhood. New vaccines have the potential to prevent the majority of these cases and could transform child health.
- Andrew J. Pollard
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News & Views |
Do steroids benefit patients with bacterial meningitis?
Bacterial meningitis causes substantial neurological morbidity and mortality worldwide. The use of corticosteroids as adjunctive therapy to antibiotics has been studied in clinical trials and debated for decades. A new meta-analysis attempts to reconcile some of the disparate findings from trials in this field.
- Vincent Quagliarello
- & W. Michael Scheld
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Case Study |
Extreme hypoglycorrhachia: not always bacterial meningitis
Extreme hypoglycorrhachia is usually caused by bacterial meningitis; however, suspicion should be raised if a patient with persistent extreme hypoglycorrhachia, pleocytosis and negative microbiological studies remains refractory to antimicrobial therapy. Viola describes the case of a 55-year-old man with chronic leptomeningitis and persistent hypoglycorrhachia, who was found to have Currarino syndrome. This syndrome is a complex genetic disorder that includes the following triad: sacral bony defect, presacral mass, and an anorectal malformation. Leptomeningitis in this patient was attributed to cholesterol crystals contained in a large presacral cyst with a communicating fistula to the CNS.
- George M. Viola
Neurological manifestations of rhino-oculo-cerebral mucormycosis in the COVID-19 era