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| Open AccessFluopack screening platform for unbiased cellular phenotype profiling
- Zhao B. Kang
- , Ioannis Moutsatsos
- & Christophe Antczak
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| Open AccessLethal methemoglobinemia in the invasive brown treesnake after acetaminophen ingestion
- Tom Mathies
- & Richard E. Mauldin
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| Open AccessPrecise safety pharmacology studies of lapatinib for onco-cardiology assessed using in vivo canine models
- Kentaro Ando
- , Takeshi Wada
- & Xin Cao
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| Open AccessMn-TAT PTD-Ngb attenuates oxidative injury by an enhanced ROS scavenging ability and the regulation of redox signaling pathway
- Cui Zhang
- , Xuehui Hao
- & Zhilin Wang
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| Open AccessDisordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
- Kidae Kim
- , Dong Ho Lee
- & Jeong-Hoon Kim
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| Open AccessTryptone-stabilized gold nanoparticles induce unipolar clustering of supernumerary centrosomes and G1 arrest in triple-negative breast cancer cells
- J. Grace Nirmala
- & Manu Lopus
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| Open AccessThe α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa
- Mriga Dutt
- , Jean Giacomotto
- & Richard J. Lewis
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| Open AccessWhole-body exposures to radiofrequency-electromagnetic energy can cause DNA damage in mouse spermatozoa via an oxidative mechanism
- Brendan J. Houston
- , Brett Nixon
- & Geoffry N. De Iuliis
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| Open AccessVEGF/Flk1 Mechanism is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis
- Shihao Chen
- , Jinge Xu
- & Yumei Zhang
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| Open AccessAtomistic simulations shed new light on the activation mechanisms of RORγ and classify it as Type III nuclear hormone receptor regarding ligand-binding paths
- Suwipa Saen-Oon
- , Estrella Lozoya
- & Robert Soliva
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| Open AccessA suicide inhibitor of nematode trehalose-6-phosphate phosphatases
- Megan Cross
- , Mark York
- & Andreas Hofmann
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| Open AccessThe subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals
- Beata Greb-Markiewicz
- , Wioletta Kazana
- & Andrzej Ożyhar
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| Open AccessAntimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases
- Tomás Herraiz
- , Hugo Guillén
- & Vicente J. Arán
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| Open AccessThe anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells
- Sergio Oddi
- , Lucia Scipioni
- & Mauro Maccarrone
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| Open AccessMinimization of energy transduction confers resistance to phosphine in the rice weevil, Sitophilus oryzae
- Kyeongnam Kim
- , Jeong Oh Yang
- & Sung-Eun Lee
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| Open AccessBiphasic adverse effect of titanium nanoparticles on testicular function in mice
- Nobuhiko Miura
- , Katsumi Ohtani
- & Gi-Wook Hwang
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| Open AccessEnhancement of exfoliating efficacy of L-carnitine with ion-pair method monitored by nuclear magnetic resonance spectroscopy
- Sohyun In
- , Naeun Yook
- & Nae-Gyu Kang
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| Open AccessAn anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis
- Vojtech Novohradsky
- , Lenka Markova
- & Jana Kasparkova
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| Open AccessMultilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism
- Gabriel Fenteany
- , Paras Gaur
- & Lajos Haracska
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| Open AccessConstitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis
- Lars Karlsson
- , María Nazareth González-Alvarado
- & Hans Georg Kuhn
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| Open AccessPlant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
- Vivek Halder
- , Mohamed N. S. Suliman
- & Markus Kaiser
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| Open AccessThe molecular nature of the 17β-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel β1 subunit
- Sara T. Granados
- , Karen Castillo
- & Yolima P. Torres
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| Open AccessYeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12
- Naomi Abe-Kanoh
- , Narumi Kunisue
- & Yoshimasa Nakamura
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| Open AccessNicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening
- Daisuke Yamaguchi
- , Takamichi Imaizumi
- & Kazuo Kubo
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| Open AccessFABP1 controls hepatic transport and biotransformation of Δ9-THC
- Matthew W. Elmes
- , Lauren E. Prentis
- & Martin Kaczocha
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| Open AccessEnvironmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA)
- Heli Routti
- , Mari K. Berg
- & Anders Goksøyr
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| Open AccessA bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology
- Yantao Sun
- & Jie Yang
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| Open AccessPhenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity
- T. Tristan Brandhorst
- , Iain R. L. Kean
- & Bruce S. Klein
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| Open AccessUrtica dioica L. inhibits proliferation and enhances cisplatin cytotoxicity in NSCLC cells via Endoplasmic Reticulum-stress mediated apoptosis
- Brigida D’Abrosca
- , Vincenza Ciaramella
- & Floriana Morgillo
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| Open AccessAnti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation
- Quentin Spillier
- , Didier Vertommen
- & Raphaël Frédérick
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| Open AccessMethylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells
- Min-Seok Kim
- , Tsutomu Takahashi
- & Gi-Wook Hwang
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| Open AccessPro-angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1
- Ji In Kang
- , Yoonjung Choi
- & Ho Min Kim
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| Open AccessA Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
- Indrani Pal
- , Dipita Bhattacharyya
- & Hanudatta S. Atreya
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| Open AccessThe influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa
- Emily A. Ridge
- , Sudhan Pachhain
- & Jon E. Sprague
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| Open AccessDiscovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
- Katherine A. Vousden
- , Tomas Lundqvist
- & Tristan J. Vaughan
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| Open AccessOxo-aglaiastatin-Mediated Inhibition of Translation Initiation
- Rayelle Itoua Maïga
- , Regina Cencic
- & Jerry Pelletier
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| Open AccessThe neurotoxic secreted phospholipase A2 from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria
- Jernej Šribar
- , Lidija Kovačič
- & Igor Križaj
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| Open AccessAntrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells
- Dai-Hua Tsai
- , Cheng-Han Chung
- & Kung-Ta Lee
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| Open AccessUnderstanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers
- Etsuko Tokunaga
- , Takeshi Yamamoto
- & Norio Shibata
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| Open AccessChronic exposure to imidacloprid or thiamethoxam neonicotinoid causes oxidative damages and alters carotenoid-retinoid levels in caged honey bees (Apis mellifera)
- Maxime Gauthier
- , Philippe Aras
- & Monique Boily
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| Open AccessTuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms
- Marc-Philipp Pfeil
- , Alice L. B. Pyne
- & Maxim G. Ryadnov
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| Open AccessCell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells
- Chiaki Fujiwara
- , Yukiko Muramatsu
- & Hiroyuki Seimiya
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| Open AccessCrown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells
- Iva Guberović
- , Marko Marjanović
- & Marijeta Kralj
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| Open AccessAnti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation
- Jun-ichiro Suzuki
- , Yukihiro Kodera
- & Naoaki Morihara
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| Open AccessWhole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes
- Olli Kärkkäinen
- , Tomi Tuomainen
- & Kati Hanhineva
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| Open AccessGerminated soy germ with increased soyasaponin Ab improves BMP-2-induced bone formation and protects against in vivo bone loss in osteoporosis
- Chan-Woong Choi
- , Sik-Won Choi
- & Woo-Duck Seo
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| Open AccessA Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction
- Keisuke Kobayashi
- , Satoshi Ohte
- & Hiroshi Tomoda
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| Open AccessTributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells
- Shigeru Yamada
- , Yusuke Kubo
- & Yasunari Kanda
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| Open AccessSmall molecule activator of Nm23/NDPK as an inhibitor of metastasis
- Jae-Jin Lee
- , Hwang Suk Kim
- & Kong-Joo Lee