Lymphopoiesis articles within Nature

Featured

• Article | 21 November 2022

  Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation

  Aberrant thymocyte developmental programming results when interactions between thymic stroma and pre-T cell receptors occur in the absence of major histocompatibility complex bound to antigen peptide.

  • Jonathan S. Duke-Cohan
  • , Aoi Akitsu
  •  & Ellis L. Reinherz

• Article
  10 August 2022 | Open Access

  Diverse mutational landscapes in human lymphocytes

  Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher burdens in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency.

  • Heather E. Machado
  • , Emily Mitchell
  •  & Peter J. Campbell

• Article | 24 February 2021

  A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

  A peri-arteriolar niche in the bone marrow for osteogenesis and lymphopoiesis is maintained by mechanical stimulation and is depleted during ageing.

  • Bo Shen
  • , Alpaslan Tasdogan
  •  & Sean J. Morrison

• Letter | 29 September 2016

  Single-cell RNA-seq identifies a PD-1^hi ILC progenitor and defines its development pathway

  Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs can also be depleted by a PD-1 antibody.

  • Yong Yu
  • , Jason C. H. Tsang
  •  & Pentao Liu

• Letter | 03 April 2013

  Diverse and heritable lineage imprinting of early haematopoietic progenitors

  In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.

  • Shalin H. Naik
  • , Leïla Perié
  •  & Ton N. Schumacher