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News & Views |
Lipid nanodiscs give cancer a STING
Lipid nanodiscs carrying a potent STING agonist penetrate deep into solid tumours compared with gold-standard liposomes and enable long-term antitumour immunotherapy.
- Ningqiang Gong
- & Michael J. Mitchell
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Article
| Open Access
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
Here the authors investigate lipid nanodiscs as drug carriers for antitumour immunotherapy. They demonstrate that flexible lipid nanodiscs functionalized with STING-activating cyclic dinucleotides exhibit superior tumour penetration and tumour cell uptake compared with spherical liposomes, resulting in improved antitumour T-cell priming and tumour regression.
- Eric L. Dane
- , Alexis Belessiotis-Richards
- & Darrell J. Irvine
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Article |
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
Islet transplantation for diabetes treatment requires immunosuppression to control rejection. A microgel presenting Fas ligand with immunomodulatory properties is now shown to prolong the survival of allogeneic islet grafts in vivo.
- Devon M. Headen
- , Kyle B. Woodward
- & Haval Shirwan
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Article |
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
By studying the immune responses of animals to different types of biomaterial implants, colony stimulating factor-1 receptor is revealed as an important mediator of the foreign body reaction and a possible target for fibrosis inhibition.
- Joshua C. Doloff
- , Omid Veiseh
- & Daniel G. Anderson
Immunoengineering can overcome the glycocalyx armour of cancer cells