Hypertension articles within Nature

Featured

• Article | 15 November 2017

  Salt-responsive gut commensal modulates T_H17 axis and disease

  High salt intake changed the gut microbiome and increased T_H17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of T_H17 cells and increased blood pressure in humans.

  • Nicola Wilck
  • , Mariana G. Matus
  •  & Dominik N. Müller

• Letter | 28 September 2016

  Genome-wide associations for birth weight and correlations with adult disease

  Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

  • Momoko Horikoshi
  • , Robin N. Beaumont
  •  & Rachel M. Freathy

• Outlook | 30 January 2013

  Drugs: Blood battles

  The standard medications for hypertension and cholesterol have lingering issues, but new drugs hold promise for high-risk patients.

  • Katharine Gammon

• Article | 09 May 2012

  Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

  Evidence from mice and humans indicates that peripartum cardiomyopathy (PPCM) is a vascular disease caused by excessive anti-angiogenic signalling in the peripartum period of pregnancy and that pre-eclampsia and multiple gestation are important risk factors for the development of PPCM.

  • Ian S. Patten
  • , Sarosh Rana
  •  & Zoltan Arany

• Letter | 21 March 2012

  Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy

  Pregnant corin- or ANP-deficient mice have impaired trophoblast invasion and uterine spiral artery remodelling, and patients with pre-eclampsia have lower uterine corin messenger RNA and protein levels than normal pregnancies, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.

  • Yujie Cui
  • , Wei Wang
  •  & Qingyu Wu

• Letter | 22 January 2012

  Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

  Exome sequencing identifies mutations in kelch-like 3 and cullin 3 as causes of a syndrome featuring high blood pressure and electrolyte abnormalities.

  • Lynn M. Boyden
  • , Murim Choi
  •  & Richard P. Lifton

• Research Highlights | 01 December 2010

  Medicine: Profiling for blood pressure

• Letter | 06 October 2010

  A redox switch in angiotensinogen modulates angiotensin release

  Angiotensins have a crucial role in blood pressure regulation and are generated by cleavage of a larger protein, angiotensinogen, by the enzyme renin. Structures of angiotensinogen alone and in complex with renin show that a large conformational change is required to expose the renin-cleavage site. The authors also show that this transition is regulated by oxidation and that women with pre-eclampsia have higher levels of the more active, oxidized, form.

  • Aiwu Zhou
  • , Robin W. Carrell
  •  & Randy J. Read

• Research Highlights | 05 May 2010

  Genomics: Rat sequencing redux