Genetic interaction articles within Nature Communications

Featured

• Article
  11 July 2013 | Open Access

  Genome evolution predicts genetic interactions in protein complexes and reveals cancer drug targets

  Genetic interactions can reveal insights into cellular functions. Here, Lu et al.show that negative genetic interactions in protein complexes can be predicted by systematically exploring the evolutionary history of genes, which may be useful for the identification of novel targets for anti-cancer drugs.

  • Xiaowen Lu
  • , Philip R. Kensche
  •  & Richard A. Notebaart

• Article
  05 March 2013 | Open Access

  The interaction between OsMADS57 and OsTB1 modulates rice tillering via DWARF14

  Tillering is a multigenic complex trait that influences grain yield in cereal; however, the molecular network for its regulation remains unclear. Guo et al.show that OsMADS57, a transcription factor controlled by miR444a, interacts with OsTEOSINTE BRANCHED1 and targets DWARF14 to control tillering in rice.

  • Siyi Guo
  • , Yunyuan Xu
  •  & Kang Chong

• Article | 04 May 2010

  USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis

  The ubiquitin-like modifier FAT10 targets proteins for proteolytic degradation. Here the ubiquitin-conjugating enzyme USE1 is identified as a component of the FAT10 conjugation cascade.

  • Annette Aichem
  • , Christiane Pelzer
  •  & Marcus Groettrup