Extracellular matrix articles within Nature

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• Article | 02 September 2020

  Mechanics of a multilayer epithelium instruct tumour architecture and function

  Mathematical and experimental approaches are used to investigate the mechanical forces that shape the tumour architecture of two different common forms of skin cancer: basal cell carcinomas and invasive squamous cell carcinomas.

  • Vincent F. Fiore
  • , Matej Krajnc
  •  & Elaine Fuchs

• Letter | 19 June 2013

  High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

  Naked mole rats seem almost entirely protected from developing cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the extracellular matrix; together with an increased sensitivity of naked mole-rat cells to hyaluronan signalling, this form protects its cells from oncogenic transformation.

  • Xiao Tian
  • , Jorge Azpurua
  •  & Andrei Seluanov