Evolutionary genetics articles within Nature

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  • Article
    | Open Access

    A strong association has been found between three regions of the Plasmodium falciparum genome and sickle haemoglobin in children with severe malaria, suggesting parasites have adapted to overcome natural host immunity.

    • Gavin Band
    • , Ellen M. Leffler
    •  & Dominic P. Kwiatkowski

  • Article
    | Open Access

    A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • , Theo Sanderson
    •  & Moritz Gerstung

  • Article
    | Open Access

    A revised, universal nomenclature for the vertebrate genes that encode the oxytocin and vasopressin–vasotocin ligands and receptors will improve our understanding of gene evolution and facilitate the translation of findings across species.

    • Constantina Theofanopoulou
    • , Gregory Gedman
    •  & Erich D. Jarvis

  • Article |

    Genomic analyses of human populations in the Pacific provide insights into the peopling history of the region and reveal episodes of biological adaptation relating to the immune system and lipid metabolism through introgression from archaic hominins and polygenic adaptation.

    • Jeremy Choin
    • , Javier Mendoza-Revilla
    •  & Lluis Quintana-Murci

  • Article
    | Open Access

    The complete assembly of human chromosome 8 resolves previous gaps and reveals hidden complex forms of genetic variation, enabling functional and evolutionary characterization of primate centromeres.

    • Glennis A. Logsdon
    • , Mitchell R. Vollger
    •  & Evan E. Eichler

  • Article |

    The routes and lengths of migrations of Eurasian Arctic peregrine falcons have probably been shaped by climate change across the Last Glacial Maximum–Holocene transition and by selection for long-term memory acting on ADCY8, respectively.

    • Zhongru Gu
    • , Shengkai Pan
    •  & Xiangjiang Zhan

  • Article |

    Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

    • Chuan-Chao Wang
    • , Hui-Yuan Yeh
    •  & David Reich

  • Article |

    Siberian mammoth genomes from the Early and Middle Pleistocene subepochs reveal adaptive changes and a key hybridization event, highlighting the value of deep-time palaeogenomics for studies of speciation and long-term evolutionary trends.

    • Tom van der Valk
    • , Patrícia Pečnerová
    •  & Love Dalén

  • Review Article |

    A Review describes the three key phases that define the origins of modern human ancestry, and highlights the importance of analysing both palaeoanthropological and genomic records to further improve our understanding of our evolutionary history.

    • Anders Bergström
    • , Chris Stringer
    •  & Pontus Skoglund

  • Article
    | Open Access

    The genome of the biofuel crop switchgrass (Panicum virgatum) reveals climate–gene–biomass associations that underlie adaptation in nature and will facilitate improvements of the yield of this crop for bioenergy production.

    • John T. Lovell
    • , Alice H. MacQueen
    •  & Jeremy Schmutz

  • Perspective |

    Unique biological traits of bats and adaptive evolution associated with flight confer immunotolerance of viral infection that may help to make bats special reservoir hosts for viruses.

    • Aaron T. Irving
    • , Matae Ahn
    •  & Lin-Fa Wang

  • Article
    | Open Access

    A chromosome-quality genome of the lungfish Neoceratodus fosteri sheds light on the development of obligate air-breathing and the gain of limb-like gene expression in lobed fins, providing insights into the water-to-land transition in vertebrate evolution.

    • Axel Meyer
    • , Siegfried Schloissnig
    •  & Manfred Schartl

  • Article |

    Dire wolves split from living canids around 5.7 million years ago and originated in the New World isolated from the ancestors of grey wolves and coyotes, which evolved in Eurasia and colonized North America only relatively recently.

    • Angela R. Perri
    • , Kieren J. Mitchell
    •  & Laurent A. F. Frantz

  • Article
    | Open Access

    New reference genomes of the two extant monotreme lineages (platypus and echidna) reveal the ancestral and lineage-specific genomic changes that shape both monotreme and mammalian evolution.

    • Yang Zhou
    • , Linda Shearwin-Whyatt
    •  & Guojie Zhang

  • Article |

    Ancient DNA reveals genetic differences between stone-tool users and people associated with ceramic technology in the Caribbean and provides substantially lower estimates of population sizes in the region before European contact.

    • Daniel M. Fernandes
    • , Kendra A. Sirak
    •  & David Reich

  • Article |

    A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

    • Shaohong Feng
    • , Josefin Stiller
    •  & Guojie Zhang

  • Article |

    A yeast clonal descendant of an ancient hybridization event is identified and sheds light on the early evolution of the Saccharomyces cerevisiae Alpechin lineage and its abundant Saccharomyces paradoxus introgressions.

    • Melania D’Angiolo
    • , Matteo De Chiara
    •  & Gianni Liti

  • Analysis
    | Open Access

    A whole-genome alignment of 240 phylogenetically diverse species of eutherian mammal—including 131 previously uncharacterized species—from the Zoonomia Project provides data that support biological discovery, medical research and conservation.

    • Diane P. Genereux
    • , Aitor Serres
    •  & Elinor K. Karlsson

  • Article |

    Whole-genome sequencing analyses of African populations provide insights into continental migration, gene flow and the response to human disease, highlighting the importance of including diverse populations in genomic analyses to understand human ancestry and improve health.

    • Ananyo Choudhury
    • , Shaun Aron
    •  & Neil A. Hanchard

  • Article |

    Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

    • Alexander G. Ioannidis
    • , Javier Blanco-Portillo
    •  & Andrés Moreno-Estrada

  • Article |

    Resequencing analyses of three species of wild sunflower identify large non-recombining haplotype blocks that correlate with ecologically relevant traits, soil and climate characteristics, and that differentiate species ecotypes.

    • Marco Todesco
    • , Gregory L. Owens
    •  & Loren H. Rieseberg

  • Article |

    Experimental analysis of reconstructed ancestral globins reveals that haemoglobin’s complex tetrameric structure and oxygen-binding functions evolved by simple genetic and biophysical mechanisms.

    • Arvind S. Pillai
    • , Shane A. Chandler
    •  & Joseph W. Thornton

  • Article |

    Analyses of the proteomes of dental enamel from Homo antecessor and Homo erectus demonstrate that the Early Pleistocene H. antecessor is a close sister lineage of later Homo sapiens, Neanderthal and Denisovan populations in Eurasia.

    • Frido Welker
    • , Jazmín Ramos-Madrigal
    •  & Enrico Cappellini

  • Article |

    SARS-CoV-2-related coronaviruses are identified in Malayan pangolins (Manis javanica); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2.

    • Tommy Tsan-Yuk Lam
    • , Na Jia
    •  & Wu-Chun Cao

  • Article |

    Analyses of mitochondrial genomes from populations in southern Africa provide evidence of a southern African origin of anatomically modern humans and a sustained occupation of the homeland before the first migrations of people appear to be driven by regional climate shifts.

    • Eva K. F. Chan
    • , Axel Timmermann
    •  & Vanessa M. Hayes

  • Letter |

    The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.

    • Moises Exposito-Alonso
    • , Moises Exposito-Alonso
    •  & Detlef Weigel

  • Article |

    The transcriptomes of seven major organs across developmental stages from several mammalian species are used for comparative analyses of gene expression and evolution across organ development.

    • Margarida Cardoso-Moreira
    • , Jean Halbert
    •  & Henrik Kaessmann

  • Article |

    Analyses of 34 ancient genomes from northeastern Siberia, dating to between 31,000 and 600 years ago, reveal at least three major migration events in the late Pleistocene population history of the region.

    • Martin Sikora
    • , Vladimir V. Pitulko
    •  & Eske Willerslev

  • Letter |

    A single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution during treatment with ibrutinib.

    • Federico Gaiti
    • , Ronan Chaligne
    •  & Dan A. Landau

  • Letter |

    Fossil evidence indicates that Denisovans occupied the Tibetan Plateau in the Middle Pleistocene epoch and successfully adapted to this high-altitude hypoxic environments long before the regional arrival of modern Homo sapiens.

    • Fahu Chen
    • , Frido Welker
    •  & Jean-Jacques Hublin

  • Article |

    In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

    • Akira Yokoyama
    • , Nobuyuki Kakiuchi
    •  & Seishi Ogawa

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