Developmental biology articles within Nature Materials

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  • Article
    | Open Access

    Collective cell migration in embryonic tissues is triggered by cell softening due to a microtubule deacetylation pathway involving the mechanosensitive ion channel Piezo1.

    • Cristian L. Marchant
    • , Abdul N. Malmi-Kakkada
    •  & Elias H. Barriga

  • Article |

    The influence of stress relaxation of the extracellular matrix on the formation of intestinal organoids was investigated. It was shown that a stress-relaxing synthetic matrix promotes crypt budding through increased symmetry breaking and niche cell formation.

    • Antonius Chrisnandy
    • , Delphine Blondel
    •  & Matthias P. Lutolf

  • Review Article |

    This Review highlights the recent emergence of stem-cell-derived embryo models for the purpose of advancing our understanding of mammalian embryology as well as their potential uses in regenerative and reproductive medicine.

    • Jianping Fu
    • , Aryeh Warmflash
    •  & Matthias P. Lutolf

  • News & Views |

    Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

    • Sayan Chakraborty
    •  & Wanjin Hong

  • News & Views |

    Epithelial layers under compression avoid buckling by active contraction, but only up to a well-defined threshold at 35% strain, beyond which buckling occurs.

    • Ulrich S. Schwarz

  • Article |

    Epithelial tissues behave as pre-tensed viscoelastic sheets that can buffer against compression and rapidly recover from buckling. Epithelial mechanical properties define a tissue-intrinsic buckling threshold that dictates the compressive strain above which tissue folds become permanent.

    • Tom P. J. Wyatt
    • , Jonathan Fouchard
    •  & Guillaume T. Charras

  • News & Views |

    A two-step method has been developed for the accelerated and efficient generation of human kidney organoids using in vitro and in ovo culture in a three-dimensional environment.

    • Susana M. Chuva de Sousa Lopes

  • News & Views |

    A micropatterned human pluripotent stem cell-based developmental model was utilized to demonstrate the role of biophysical cues such as cell size and cytoskeletal contractile forces in directing patterning of neuroepithelial and neural plate border cells.

    • Mukul Tewary
    •  & Peter W. Zandstra

  • News & Views |

    Using a biomimetic culture platform to replicate the early biophysical environment of a developing embryo, human pluripotent stem cells can be directed towards amnion formation in vitro.

    • Martin Pera

  • News & Views |

    Technologies to isolate colonies of human pluripotent stem cells from other cell types in a high-throughput manner are lacking. A microfluidic-based approach that exploits differences in the adhesion strength between these cells and a substrate may soon fill the gap.

    • Oscar J. Abilez
    •  & Joseph C. Wu

  • Article |

    Structure–property relationships between material properties and stem cell behaviour are investigated using high-throughput methods. The data identify the optimal substrates within a range of different polymeric surfaces to support the growth and self-renewal of human embryonic stem cells from fully dissociated single cells.

    • Ying Mei
    • , Krishanu Saha
    •  & Daniel G. Anderson

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