Corneal diseases articles within Nature

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• Letter | 09 March 2016

  Co-ordinated ocular development from human iPS cells and recovery of corneal function

  A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.

  • Ryuhei Hayashi
  • , Yuki Ishikawa
  •  & Kohji Nishida

• Letter | 02 July 2014

  ABCB5 is a limbal stem cell gene required for corneal development and repair

  The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.

  • Bruce R. Ksander
  • , Paraskevi E. Kolovou
  •  & Natasha Y. Frank