The mechanisms underlying motor arrest are unclear. Here, the authors show that Chx10+ neurons in the mouse pedunculopontine nucleus control global motor arrest in a pattern of pause (movement on hold) and play (movement resuming from the exact position it paused) likely in response to salient and nonthreatening environmental cues.
- Haizea Goñi-Erro
- Raghavendra Selvan
- Ole Kiehn