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| Open AccessIdentifying intracellular signaling modules and exploring pathways associated with breast cancer recurrence
- Xi Chen
- , Jinghua Gu
- & Jianhua Xuan
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| Open AccessRegulators of TNFα mediated insulin resistance elucidated by quantitative proteomics
- Rodrigo Mohallem
- & Uma K. Aryal
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| Open AccessAn improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae
- José Córdoba-Caballero
- , Pedro Seoane
- & M. Gonzalo Claros
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| Open AccessCell shape regulates subcellular organelle location to control early Ca2+ signal dynamics in vascular smooth muscle cells
- R. C. Calizo
- , M. K. Bell
- & R. Iyengar
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| Open AccessComputational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways
- Francisco das Chagas Pereira de Andrade
- & Anderson Nogueira Mendes
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| Open AccessA computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma
- Dayana Herrera-Rios
- , Guanzhang Li
- & Ulf Dietrich Kahlert
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| Open AccessTranscriptomic determinants of the response of ST-111 Pseudomonas aeruginosa AG1 to ciprofloxacin identified by a top-down systems biology approach
- José Arturo Molina-Mora
- , Diana Chinchilla-Montero
- & Fernando García
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| Open AccessiPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome
- Yekaterina Galat
- , Mariana Perepitchka
- & Vasiliy Galat
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| Open AccessIL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma
- Yuxuan Wang
- , Chengcheng Wang
- & Liang Wu
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| Open AccessTranscriptional and in silico analyses of MIF cytokine and TLR signalling interplay in the LPS inflammatory response of Ciona robusta
- Vincenzo Arizza
- , Angela Bonura
- & Aiti Vizzini
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| Open AccessULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins
- Amanda Demeter
- , Mari Carmen Romero-Mulero
- & Tamás Korcsmáros
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Article
| Open AccessBinding of Filamentous Actin to CaMKII as Potential Regulation Mechanism of Bidirectional Synaptic Plasticity by β CaMKII in Cerebellar Purkinje Cells
- Thiago M. Pinto
- , Maria J. Schilstra
- & Volker Steuber
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| Open AccessModulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model
- Flavio Lichtenstein
- , Asif Iqbal
- & Ana Marisa Chudzinski-Tavassi
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| Open AccessA novel diagnostic system to evaluate epidermal growth factor receptor impact as a prognostic and therapeutic indicator for lung adenocarcinoma
- Kazuya Takakuwa
- , Kaoru Mogushi
- & Shigeo Yamaguchi
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| Open AccessRobustness in spatially driven bistability in signaling systems
- Debora Tenenbaum
- , Juan Ignacio Marrone
- & Alejandra C. Ventura
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| Open AccessA Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks
- Lior Zimmerman
- , Ori Zelichov
- & Gabi Tarcic
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Article
| Open AccessCommon and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression
- Divya Niveditha
- , Mayank Jasoria
- & Shibasish Chowdhury
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Article
| Open AccessGenome-wide inference of the Camponotus floridanus protein-protein interaction network using homologous mapping and interacting domain profile pairs
- Shishir K. Gupta
- , Mugdha Srivastava
- & Thomas Dandekar
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Article
| Open AccessMachine Learning and Network Analyses Reveal Disease Subtypes of Pancreatic Cancer and their Molecular Characteristics
- Musalula Sinkala
- , Nicola Mulder
- & Darren Martin
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| Open AccessTranscriptomic changes during TGF-β-mediated differentiation of airway fibroblasts to myofibroblasts
- Erin Joanne Walker
- , Deborah Heydet
- & Reena Ghildyal
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| Open AccessUsing mechanistic models for the clinical interpretation of complex genomic variation
- María Peña-Chilet
- , Marina Esteban-Medina
- & Joaquín Dopazo
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Article
| Open AccessExtracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence
- Jinsen Lu
- , Jiazhao Yang
- & Shiyuan Fang
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| Open AccessRegulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines
- Isar Nassiri
- , Alberto Inga
- & Corrado Priami
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| Open AccessTranscriptome Network Analysis Identifies CXCL13-CXCR5 Signaling Modules in the Prostate Tumor Immune Microenvironment
- Adaugo Q. Ohandjo
- , Zongzhi Liu
- & James W. Lillard Jr.
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| Open AccessFractional Deletion of Compound Kushen Injection Indicates Cytokine Signaling Pathways are Critical for its Perturbation of the Cell Cycle
- T. N. Aung
- , S. Nourmohammadi
- & D. L. Adelson
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Article
| Open AccessApatinib Mesylate in the treatment of advanced progressed lung adenocarcinoma patients with EGFR-TKI resistance —A Multicenter Randomized Trial
- Ping Fang
- , Liqin Zhang
- & Hongbao Cao
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Article
| Open AccessMolecular phenotyping using networks, diffusion, and topology: soft tissue sarcoma
- James C. Mathews
- , Maryam Pouryahya
- & Allen Tannenbaum
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Article
| Open AccessBioinformatics Unmasks the Maneuverers of Pain Pathways in Acute Kidney Injury
- Aprajita Gupta
- , Sanjeev Puri
- & Veena Puri
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| Open AccessGenetic basis of functional variability in adhesion G protein-coupled receptors
- Alexander Bernd Knierim
- , Juliane Röthe
- & Torsten Schöneberg
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| Open AccessA gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function
- James E. Koltes
- , Itika Arora
- & Sushant Bhatnagar
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Article
| Open AccessExploring Notch Pathway to Elucidate Phenotypic Plasticity and Intra-tumor Heterogeneity in Gliomas
- Saikat Chowdhury
- & Ram Rup Sarkar
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| Open AccessLabel propagation defines signaling networks associated with recurrently mutated cancer genes
- Merve Cakir
- , Sayan Mukherjee
- & Kris C. Wood
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Article
| Open AccessCombating viral contaminants in CHO cells by engineering innate immunity
- Austin W. T. Chiang
- , Shangzhong Li
- & Nathan E. Lewis
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| Open AccessDifferential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes
- Mariana Cooke
- , Victoria Casado-Medrano
- & Marcelo G. Kazanietz
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| Open AccessRoles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
- Dao-Guang Wang
- , Shaobing Wang
- & Feng Liu
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| Open AccessMeta-path Based Prioritization of Functional Drug Actions with Multi-Level Biological Networks
- Seyeol Yoon
- & Doheon Lee
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Article
| Open AccessGenome-wide Analysis Reveals DNA Methylation Alterations in Obesity Associated with High Risk of Colorectal Cancer
- Lixin Dong
- , Li Ma
- & Hongmei Ren
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| Open AccessElevated pre-activation basal level of nuclear NF-κB in native macrophages accelerates LPS-induced translocation of cytosolic NF-κB into the cell nucleus
- Alexander V. Bagaev
- , Anastasiya Y. Garaeva
- & Fazly I. Ataullakhanov
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| Open AccessPost-transcriptional regulatory patterns revealed by protein-RNA interactions
- Andreas Zanzoni
- , Lionel Spinelli
- & Christine Brun
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| Open AccessConnectivity mapping of angiotensin-PPAR interactions involved in the amelioration of non-alcoholic steatohepatitis by Telmisartan
- Jung Gyu Park
- , Jong Soo Mok
- & Joonghoon Park
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| Open AccessDRUGPATH – a novel bioinformatic approach identifies DNA-damage pathway as a regulator of size maintenance in human ESCs and iPSCs
- Boris Kovacic
- , Margit Rosner
- & Markus Hengstschläger
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| Open AccessIdentification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation
- Mengxi Lv
- , Yilu Zhou
- & X. Lucas Lu
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| Open AccessBoolean Calcium Signalling Model Predicts Calcium Role in Acceleration and Stability of Abscisic Acid-Mediated Stomatal Closure
- Pramuditha Waidyarathne
- & Sandhya Samarasinghe
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| Open AccessGenome-wide Identification of Jatropha curcas MAPK, MAPKK, and MAPKKK Gene Families and Their Expression Profile Under Cold Stress
- Haibo Wang
- , Ming Gong
- & Lizhou Tang
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| Open AccessMicroRNA induction by copy number gain is associated with poor outcome in squamous cell carcinoma of the lung
- Endi Xia
- , Sotaro Kanematsu
- & Sana Yokoi
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| Open AccessDevelopment of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping
- Blerina Ahmetaj-Shala
- , Michael Olanipekun
- & Jane A. Mitchell
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| Open AccessEmergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scales
- Tanmay Mitra
- , Shakti N. Menon
- & Sitabhra Sinha
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| Open AccessTranscriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models
- Allison N. Tegge
- , Richard R. Rodrigues
- & Padmavathy Rajagopalan