Cell signalling articles within Nature Materials

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• Article | 20 January 2020

  Protease-activated receptor signalling initiates α₅β₁-integrin-mediated adhesion in non-haematopoietic cells

  As in haematopoietic cells and platelets, agonist binding to protease-activated receptors PAR1 and PAR2 in non-haematopoietic cells also triggers signalling pathways that lead to α₅β₁-integrin-mediated cell adhesion.

  • Patrizia M. Spoerri
  • , Nico Strohmeyer
  •  & Daniel J. Müller

• Letter | 12 February 2018

  Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

  The mechanism by which cell geometry regulates cell signalling is reported to be modulated by lipid rafts within the plasma membrane, which are now shown to be responsible for geometry-dependent mesenchymal stem cell differentiation.

  • Thomas C. von Erlach
  • , Sergio Bertazzo
  •  & Molly M. Stevens

• Article | 01 May 2017

  EGFR and HER2 activate rigidity sensing only on rigid matrices

  Epidermal growth factor receptor and its isoform HER2 are recruited to nascent cellular adhesion sites and play an important role in the rigidity sensing of cells on stiff substrates, this activity being dependent on Src-mediated phosphorylation.

  • Mayur Saxena
  • , Shuaimin Liu
  •  & Michael P. Sheetz