Cell polarity articles within Nature Materials

Featured

• News & Views | 20 August 2020

  Apical poles without neighbouring cells

  Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

  • Covadonga Díaz-Díaz
  •  & Fernando Martín-Belmonte

• Article | 27 April 2020

  Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes

  The polarity of primary hepatocytes has now been shown to be inducible at the single-cell level by passive artificial micro-niches, indicating that the early development of polarity occurs largely independently of the types and response of the neighbouring cells.

  • Yue Zhang
  • , Richard De Mets
  •  & Virgile Viasnoff