Cardiomyopathies articles within Nature

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• Article
  01 November 2023 | Open Access

  Structure of the native myosin filament in the relaxed cardiac sarcomere

  A cryo-electron tomography study reports the structure of thick myosin filaments of mouse cardiac muscle in the relaxed state in situ and the MyBP-C links that connect them with the surrounding thin actin filaments.

  • Davide Tamborrini
  • , Zhexin Wang
  •  & Stefan Raunser

• Article | 31 May 2023

  Transfer learning enables predictions in network biology

  A context-aware, attention-based deep learning model pretrained on single-cell transcriptomes enables predictions in settings with limited data in network biology and could accelerate discovery of key network regulators and candidate therapeutic targets.

  • Christina V. Theodoris
  • , Ling Xiao
  •  & Patrick T. Ellinor

• Article | 22 June 2022

  Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

  • Mark Chaffin
  • , Irinna Papangeli
  •  & Patrick T. Ellinor

• Article | 26 May 2021

  MARK4 controls ischaemic heart failure through microtubule detyrosination

  MARK4 regulates cardiomyocyte contractility by promoting MAP4 phosphorylation, which facilitates the access of VASH2 to microtubules for the detyrosination of α-tubulin; MARK4 deficiency after acute myocardial infarction limits the reduction in the left ventricular ejection fraction.

  • Xian Yu
  • , Xiao Chen
  •  & Xuan Li

• Article | 05 August 2020

  Position-specific oxidation of miR-1 encodes cardiac hypertrophy

  The 8-oxoguanine modification of the microRNA miR-1 results in redirected recognition and silencing of target genes and leads to cardiac hypertrophy in mice.

  • Heeyoung Seok
  • , Haejeong Lee
  •  & Sung Wook Chi

• Article | 17 July 2019

  Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

  A disease model using cardiomyocytes derived from induced pluripotent stem cells of patients with mutated LMNA-related dilated cardiomyopathy reveals that the abnormal activation of the PDGF pathway is associated with the arrhythmic phenotypes of patients.

  • Jaecheol Lee
  • , Vittavat Termglinchan
  •  & Joseph C. Wu

• Outlook | 30 January 2013

  Pathology: At the heart of the problem

  Research is illuminating the molecular mechanisms that can cascade into debilitating heart disease.

  • Cassandra Willyard

• Letter | 27 January 2013

  Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

  This study demonstrates that an inheritable adult onset heart disease can be modelled in vitro within months with the help of metabolic maturation induction.

  • Changsung Kim
  • , Johnson Wong
  •  & Huei-Sheng Vincent Chen

• Article | 09 May 2012

  Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

  Evidence from mice and humans indicates that peripartum cardiomyopathy (PPCM) is a vascular disease caused by excessive anti-angiogenic signalling in the peripartum period of pregnancy and that pre-eclampsia and multiple gestation are important risk factors for the development of PPCM.

  • Ian S. Patten
  • , Sarosh Rana
  •  & Zoltan Arany

• Letter | 25 April 2012

  Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

  Mitochondrial DNA escaping from the autophagy pathway can trigger inflammation through Toll-like receptor (TLR) 9, leading to abnormalities in cardiac structure and function, and increased mortality.

  • Takafumi Oka
  • , Shungo Hikoso
  •  & Kinya Otsu

• News & Views | 14 March 2012

  Broken giant linked to heart failure

  Genetic mutations can cause a type of heart disease called dilated cardiomyopathy, by predisposing the organ to enlarge and function poorly. It has now been found that 27% of cases are due to mutations that disrupt the muscle protein titin.

  • Elizabeth M. McNally