Basal ganglia articles within Nature

Featured

  • Article
    | Open Access

    Photometric recordings and optogenetic manipulation show that dopamine fluctuations in the dorsolateral striatum in mice modulate the use, sequencing and vigour of behavioural modules during spontaneous behaviour.

    • Jeffrey E. Markowitz
    • , Winthrop F. Gillis
    •  & Sandeep Robert Datta

  • Article |

    In male zebra finches, song practice and courtship song performance are associated with distinct patterns of neural activity in the basal ganglia, resulting in reduced vocal variability during performance.

    • Jonnathan Singh Alvarado
    • , Jack Goffinet
    •  & Richard Mooney

  • Article
    | Open Access

    Mesoscale connectomic mapping of the cortico–basal ganglia–thalamic network reveals key architectural and information processing features.

    • Nicholas N. Foster
    • , Joshua Barry
    •  & Hong-Wei Dong

  • Article |

    Simultaneous mapping of activity across the cortex and dorsal striatum in mice shows that activity in each part of the striatum precisely mirrors that in topographically associated cortical regions, consistently across behavioural contexts.

    • Andrew J. Peters
    • , Julie M. J. Fabre
    •  & Matteo Carandini

  • Article |

    In mouse models of Parkinson’s disease and dyskinesia, striatal spiny projection neurons of the direct and indirect pathways have abnormal, imbalanced levels of spontaneous and locomotor-related activity, with the two different disease states characterized by opposite abnormalities.

    • Jones G. Parker
    • , Jesse D. Marshall
    •  & Mark J. Schnitzer

  • Letter |

    In the mouse caudal brainstem, functionally distinct neuronal subpopulations, which are distinguishable by neurotransmitter identity, connectivity and location, regulate locomotion parameters.

    • Paolo Capelli
    • , Chiara Pivetta
    •  & Silvia Arber

  • Letter |

    In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.

    • Guohong Cui
    • , Sang Beom Jun
    •  & Rui M. Costa

  • Article |

    Stress-induced behavioural measures of anhedonia in adult mice, but not measures of behavioural despair, required a decrease in the strength of excitatory synapses on D1 dopamine receptor-expressing nucleus accumbens medium spiny neurons owing to activation of melanocortin 4 receptors.

    • Byung Kook Lim
    • , Kee Wui Huang
    •  & Robert C. Malenka

  • Letter |

    In Bengalese finches, a basal ganglia circuit, the anterior forebrain pathway, can covertly acquire the ability to adaptively modify song without contributing to song production during practice or training.

    • Jonathan D. Charlesworth
    • , Timothy L. Warren
    •  & Michael S. Brainard

  • Letter |

    Neurotransmitter release and activity are modulated in the striatum of mice to demonstrate that the balance of activity within the two antagonistic, inhibitory pathways co-mingled in this nucleus regulates excitatory innervation of the basal ganglia during development.

    • Yevgenia Kozorovitskiy
    • , Arpiar Saunders
    •  & Bernardo L. Sabatini

  • Letter |

    It has long been thought that motor control is achieved through the balanced activity of two distinct pathways through the basal ganglia that have opposing effects, but this has never been functionally verified. These authors directly test this hypothesis with optogenetic activation of different populations of mouse striatal neurons, and not only trace functional connectivity but demonstrate opposing effects on motor behaviour in a parkinsonian model.

    • Alexxai V. Kravitz
    • , Benjamin S. Freeze
    •  & Anatol C. Kreitzer

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