Autoimmunity articles within Nature Communications

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• Article | 01 October 2014

  The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors

  Whether differentiation of regulatory and conventional T cells in the thymus requires similar T-cell receptor affinity is not known. Here, the authors show that cells expressing the same T-cell receptor selected on the same ligand can give rise to both lineages, but different sensitivity to negative selection separates their T-cell receptor repertoires.

  • Lukasz Wojciech
  • , Alicja Ignatowicz
  •  & Leszek Ignatowicz

• Article
  14 March 2014 | Open Access

  Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation

  Regulatory T cells (Tregs) are important for the maintenance of self-tolerance and this requires their trafficking to the lymph nodes and target tissues. Here, the authors show that the recognition of self-antigens expressed by endothelial cells in target tissue is instrumental for efficient Treg recruitment in vivo.

  • Hongmei Fu
  • , Madhav Kishore
  •  & Federica M. Marelli-Berg

• Article | 21 January 2014

  PTPN2 attenuates T-cell lymphopenia-induced proliferation

  Single nucleotide polymorphisms in the gene encoding the protein phosphatase PTPN2 are associated with autoimmunity in humans. Here, Wiede et al. show that PTPN2 suppresses the proliferative capacity of T cells in lymphopenia and prevents the development of autoimmunity resulting from overt homoeostatic proliferation.

  • Florian Wiede
  • , Nicole L. La Gruta
  •  & Tony Tiganis

• Article | 18 October 2013

  Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop

  Autoimmune T cell receptors can interact with both self and microbial antigens, but the structural basis for crossreactivity is not fully understood. Here, the authors provide structural insights into binding characteristics of the autoreactive T cell receptor Hy.1B11 to both self and pathogen-derived peptides.

  • Dhruv K. Sethi
  • , Susana Gordo
  •  & Kai W. Wucherpfennig