Asymmetric synthesis articles within Nature

Featured

• Article
  10 January 2024 | Open Access

  Catalytic asymmetric cationic shifts of aliphatic hydrocarbons

  We describe an imidodiphosphorimidate-catalysed asymmetric Wagner–Meerwein shift of aliphatic alkenyl cycloalkanes to cycloalkenes with excellent regio- and enantioselectivity.

  • Vijay N. Wakchaure
  • , William DeSnoo
  •  & Benjamin List

• Article | 18 December 2023

  A light-driven enzymatic enantioselective radical acylation

  Enzyme-bound ketyl radicals derived from thiamine diphosphate are selectively generated through single-electron oxidation by a photoexcited organic dye and shown to lead to enantioselective radical acylation reactions.

  • Yuanyuan Xu
  • , Hongwei Chen
  •  & Xiaoqiang Huang

• Article | 20 March 2023

  Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines

  The chemoselective and enantioconvergent N-alkylation of aliphatic amines, including ammonia, is achieved using chiral tridentate anionic ligands and a copper catalyst; the method shows excellent enantioselectivity and functional-group tolerance.

  • Ji-Jun Chen
  • , Jia-Heng Fang
  •  & Xin-Yuan Liu

• Article | 01 September 2021

  Enantioselective synthesis of ammonium cations

  Enantioselective supramolecular recognition allows for the asymmetric synthesis of nitrogen stereocentres, providing chiral ammonium cations in a dynamic crystallization process.

  • Mark P. Walsh
  • , Joseph M. Phelps
  •  & Matthew O. Kitching

• Article | 28 June 2021

  Photoinduced copper-catalysed asymmetric amidation via ligand cooperativity

  In the presence of three ligands and light, two distinct copper catalysts combine to produce enantioenriched secondary amides from racemic alkyl electrophiles and primary amide nucleophiles.

  • Caiyou Chen
  • , Jonas C. Peters
  •  & Gregory C. Fu

• Article | 16 October 2019

  Concise asymmetric synthesis of (−)-bilobalide

  A synthetic route to the Ginkgo biloba metabolite (−)-bilobalide is described.

  • Meghan A. Baker
  • , Robert M. Demoret
  •  & Ryan A. Shenvi

• Letter | 03 October 2018

  Asymmetric α-arylation of amino acids

  This approach introduces an aryl substituent to the α-carbon of amino acids without a transition-metal catalyst, and uses the inherent chirality of the amino acid itself as the source of asymmetry.

  • Daniel J. Leonard
  • , John W. Ward
  •  & Jonathan Clayden

• Letter | 30 July 2018

  Building C(sp³)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

  Combining cycloaddition and carbon–carbon cross-coupling offers a way of simplifying the enantioselective preparation of chemical building blocks, natural products and medicines such as the antipsychotic asenapine.

  • Tie–Gen Chen
  • , Lisa M. Barton
  •  & Phil S. Baran

• Letter | 20 November 2017

  Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds

  The functionalization of specific inert C–H bonds avoids the need for functional groups in organic synthesis and here the challenges of this approach are overcome using a dirhodium catalyst that is capable of C–H bond site-selectivity.

  • Kuangbiao Liao
  • , Thomas C. Pickel
  •  & Huw M. L. Davies

• News & Views | 17 November 2010

  Thin films with a hidden twist

  Many naturally occurring substances have a 'handedness' that enables them to interact highly specifically with matter or light. The helical features responsible for this can now be replicated in solid, porous films. See Letter p.422

  • Andreas Stein