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Neurotensin orchestrates valence assignment in the amygdala
In mouse brain, neurotensin released into the basolateral amygdala by neurons in the paraventricular nucleus of the thalamus assigns positive or negative valence during associative learning.
- Hao Li
- , Praneeth Namburi
- & Kay M. Tye
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Intercalated amygdala clusters orchestrate a switch in fear state
Distinct clusters of inhibitory neurons in the mouse amygdala perform opposing roles in fear extinction.
- Kenta M. Hagihara
- , Olena Bukalo
- & Andrew Holmes
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Letter |
The coding of valence and identity in the mammalian taste system
The identity and hedonic value of tastes are encoded in distinct neural substrates; in mice, the amygdala is necessary and sufficient to drive valence-specific behaviours in response to bitter or sweet taste stimuli, and the cortex can independently represent taste identity.
- Li Wang
- , Sarah Gillis-Smith
- & Charles S. Zuker
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Letter |
A competitive inhibitory circuit for selection of active and passive fear responses
Competitive circuits in the amygdala of mice drive either freezing or flight behaviour in response to threat, and involve distinct neuronal subtypes.
- Jonathan P. Fadok
- , Sabine Krabbe
- & Andreas Lüthi
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Letter |
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
- Garret D. Stuber
- , Dennis R. Sparta
- & Antonello Bonci
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Letter |
City living and urban upbringing affect neural social stress processing in humans
- Florian Lederbogen
- , Peter Kirsch
- & Andreas Meyer-Lindenberg
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Letter |
Neuropsin cleaves EphB2 in the amygdala to control anxiety
- Benjamin K. Attwood
- , Julie-Myrtille Bourgognon
- & Robert Pawlak
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Letter |
Distinct representations of olfactory information in different cortical centres
- Dara L. Sosulski
- , Maria Lissitsyna Bloom
- & Sandeep Robert Datta
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Letter |
Amygdala circuitry mediating reversible and bidirectional control of anxiety
The amygdala, a brain region important for learning fearful memories, is thought to have a role in generalized anxiety, but the critical subregions and connections are unknown. This paper shows that optogenetic stimulation of basolateral amygdala (BLA) terminals in the central nucleus of the amygdala of rats with channelrhodopsin has an anxiolytic effect, whereas inhibition of the same projection with eNpHR3.0 increases anxiety related behaviours. These effects were not observed with direct optogenetic control of BLA somata themselves, indicating that selective activation of certain connections can have different effects.
- Kay M. Tye
- , Rohit Prakash
- & Karl Deisseroth
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Article |
Encoding of conditioned fear in central amygdala inhibitory circuits
The central amygdala relies on inhibitory circuitry to encode fear memories, but how this information is acquired and expressed in these connections is unknown. Two new papers use a combination of cutting-edge technologies to reveal two distinct microcircuits within the central amygdala, one required for fear acquisition and the other critical for conditioned fear responses. Understanding this architecture provides a strong link between activity in a specific circuit and particular behavioural consequences.
- Stephane Ciocchi
- , Cyril Herry
- & Andreas Lüthi
Top-down control of flight by a non-canonical cortico-amygdala pathway