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Translation elongation factor 1A (eEF1A) has a role in protein synthesis and binds to the actin cytoskeleton. Gross and Kinzy show that these functions are separable and identify specific regions of eEF1A that are important for actin binding in vivo and bundling in vitro. The bamboo trunks shown on the cover resemble the unbundled actin in cells expressing mutant eEF1A. pp 772-778
Two recent studies address how chromatin-remodeling enzymes alter nucleosomes and suggest that they anchor on the particle while translocating on the nucleosomal DNA.
DNA helicases unwind DNA by a number of mechanisms in which conformational change seems to be of central importance. Characterization of two β-hairpins and fluorescence resonance energy transfer studies of protein-DNA interactions in the minichromosome maintenance proteins afford new insights into the molecular mechanisms of these proteins.
A new study adds to our understanding of the interconnection between different nuclear processes by showing that a 'classical' metazoan precursor mRNA–processing factor functions to prevent transcription-associated genomic instability.
Biochemical and genetic data defining the assembly pathway and structural biology of the T4 tail apparatus are merging to create a four-dimensional image reconstruction. Human inventions seem to be large-scale replicas of molecular devices honed by evolution.