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Volume 12 Issue 4, April 2005

The unfurling branch of a tree fern, a native of New Zealand, resembles an end-on EM view of the proteosome capped by Blm10, a new positive activator of proteosome function in yeast. Image courtesy of R. Mann. pp 294-303

Volume 12 Issue 4

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Editorial

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Correspondence

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Book Review

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News & Views

  • The structure of the archaeal toxin-antitoxin RelB–RelE complex offers surprises about resistance mechanisms and survival under stress conditions.

    • Daniel N Wilson
    • Knud H Nierhaus
    News & Views

  • A noncoding regulatory RNA in Escherichia coli, SgrS, downregulates the message for the glucose transporter, limiting accumulation of toxic sugar phosphates. Now a new study finds that SgrS can work only when the target message is brought to the membrane by transmembrane coding regions.

    • Carin K Vanderpool
    • Susan Gottesman
    News & Views

  • Repeating RNA sequences often serve as protein targets during regulatory processes involving single-stranded RNA (ssRNA). New data on the HutP protein show how it is activated and binds a repeat-containing ssRNA. Together with previous work, these studies demonstrate the versatility of RNA-binding proteins in regulating transcription in bacteria.

    • Paul Gollnick
    • Alfred Antson
    News & Views

  • A recent study links the double-stranded RNA-binding protein Staufen (Stau) 1 and the nonsense-mediated decay factor Upf1 in a novel mRNA decay pathway. Stafen now dons two hats to participate in two different pathways—one that directs mRNA localization and one that directs mRNA decay.

    • Erika L Meyer
    • Elizabeth R Gavis
    News & Views
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