Reviews & Analysis

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  • Protein tyrosine phosphatases (PTPs) are a family of signal transduction enzymes that dephosphorylate phosphotyrosine containing proteins. Structural and kinetic studies provide a molecular understanding of how these enzymes regulate a wide range of intracellular processes.

    • David Barford
    • Zongchao Jia
    • Nicholas K. Tonks
    Progress
  • A series of new crystal structures of aminoacyl-tRNA synthetases sheds new light on the evolution of specificity in this ancient family of enzymes.

    • Stephen Cusack
    Progress