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Crystal structures of BAK core domain dimers suggest a mechanism by which lipids contribute to the oligomerization of BAK, which is essential for BAK-mediated permeabilization of the mitochondrial outer membrane.
DUOX1 is an NADPH oxidase involved in thyroid hormone production and innate host defense. Cryo-EM structures of murine DUOX1 bound to maturation factor DUOXA1 provide insights into regulation and activation of this enzyme.
Cryo-EM structures of the entire mammalian F1Fo ATPase reveal several new features and details on the proton translocation pathway and suggest a model for the opening of the permeability transition pore.
Analysis of co-occurring chromatin interactions using multi-contact 3C and polymer simulations shows that, during interphase, entanglements between chromosomes and chromosomal domains are rare.
Cryo-EM structures of diabetes-related amyloids formed by wild-type human amylin (IAPP) and its S20G variant reveal a mode for surface-templated fibril growth.
Cryo-EM structures of Cas12i in multiple functional states provide insights that might facilitate the manipulation of this type V CRISPR-Cas endonuclease for genome editing applications.
In situ cryo-ET analyses of Borrelia burgdorferi flagellar motors locked in clockwise or counterclockwise rotation provide insights into rotational switching.
A SNAP-tag approach to monitoring histone dynamics at transcriptionally active sites in human cells identifies two distinct HIRA-dependent pathways that direct H3.3 deposition or retention.
The mapping of super-enhancers (SEs) in four stages of spermatogenesis reveals how meiotic enhancers remain ‘poised’ for activation as spermatogonia enter meiosis.
Cryo-EM structures of Rag GTPases in complex with Ragulator and the cytoplasmic tail of the lysosomal solute carrier SLC38A9 show how SLC38A9 promotes Rag dimer activation, essential for mTORC1 recruitment to the lysosomal membrane.
A cryo-EM structure reveals how nucleation-promoting factor Dip1 activates Arp2/3 complex and shows the actin-related proteins in Arp2/3 in a conformation that mimics a filamentous actin dimer, thus templating nucleation.
Moderate-affinity ‘secondary’ Rbfox binding motifs regulate RNA splicing during neuronal development in a manner that is dependent on Rbfox concentration.
Cryo-EM structures of free and DNA-bound pol ζ holoenzyme from budding yeast reveal how this DNA polymerase ensures fidelity and facilitates lesion bypass during translesion DNA synthesis.
Fluorescence microscopy and kinetics analyses reveal that Aβ42 oligomers generated through secondary nucleation are responsible for membrane disruption.
Cryo-EM, X-ray crystallography and mutational analyses reveal how Dengue and Zika virus protein NS5 suppresses STAT2 activity and interferon response in host cells.
The conformational dynamics of SARS-CoV-2 spike are constrained by engineering a disulfide bond that locks the protein in a closed conformation, a strategy that was also applied to SARS-CoV and MERS-CoV.
A combination of structural and protein-chemistry approaches along with phylogenetic analyses provide insights into the specific activities of mouse tubulin tyrosine ligase-like enzymes as initiases or elongases of glutamylation.