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Against the background of the debate about the best models of stroke unit care, Lenzi and Di Piero present their argument that patients with stroke have better outcomes if their stay in a dedicated stroke unit is extended, enabling prolonged and intensive monitoring for stroke complications.
Migraine is a common neurological disorder, which, according to figures from US population studies, affects around 18% of women and 6% of men. In this Review, Stephen Silberstein highlights the approach to acute and preventive migraine treatment in the US, drawing on his own experiences at the Headache Center at Thomas Jefferson University Hospital.
In mammalian neurons, cation–chloride cotransporters (CCCs) have vital roles in regulating the intracellular chloride concentration—which in turn determines the strength and polarity of γ-aminobutyric-acid-mediated neurotransmission—and in cell volume homeostasis. In this Review, Kahle et al. consider how breakdowns of chloride homeostasis resulting from alterations in CCC activity might contribute to various neurological disorders, including seizures and neuropathic pain, and they discuss the potential of CCCs as targets for novel therapeutic strategies.
Muscle strength is believed to be an important factor contributing to postural control, yet surprisingly few studies have explicitly examined the relationship between muscle weakness and postural instability. In this article, Horlings et al. search the current literature for evidence indicating that muscle weakness is a risk factor for falls, citing studies performed in elderly individuals and in patients with focal muscular deficits. In addition, they consider the effects of muscle strength training on falls and balance measures.
This article describes the case of a 54-year-old man who experienced recurrent episodes of transient amnesia over a number of years. The patient was diagnosed with transient epileptic amnesia, and his case provides the first radiological evidence that this syndrome can result from seizure activity in the hippocampus.
