Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The future of the Wada test as a predictor of verbal memory function following epilepsy surgery has been debated for some time. Memory mapping based on functional MRI is emerging as a potential alternative. Here, Andres Kanner examines where functional MRI currently stands in this setting.
Bulbar symptoms such as impaired swallowing and speech impairment are frequent features of amyotrophic lateral sclerosis and can markedly reduce life expectancy and quality of life. In this article, Kühnlein et al. highlight the importance of early detection, as well as appropriate treatment and management, of bulbar symptoms in patients with amyotrophic lateral sclerosis, emphasizing the benefits of a multidisciplinary approach.
Central retinal artery occlusion (CRAO) is an acute stroke of the eye that can result in profound visual impairment. Standard noninvasive therapies do not markedly alter the natural history of CRAO, and this has prompted investigations into new treatment strategies. As Chen and Lee discuss in this Review, thrombolytic therapy—especially local intra-arterial fibrinolysis—is showing considerable promise for the acute management of acute CRAO.
Regulatory T (TREG) cells are emerging as key players in the pathogenetic scenario of CNS autoimmune inflammation. In this article, Zozulya and Wiendl discuss how TREG-cell dysfunction might influence the disease course in multiple sclerosis and experimental autoimmune encephalomyelitis, highlighting the importance of interactions between TREGcells and dendritic cells. The authors also assess the potential for therapeutic use of these cell types in patients with multiple sclerosis.
This Case Study describes a 70-year-old immunocompetent male with rapidly-progressing dementia. Creutzfeldt–Jakob disease was suspected, but a diagnosis of enterovirus encephalitis was confirmed by brain biopsy. The authors discuss the diagnostic challenges presented by this case, and briefly review enteroviral infections of the brain.
