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MRI has a pivotal role in the diagnosis of CNS disorders but has only recently been applied to diseases of the peripheral nervous system. Martin Bendszus and Guido Stoll discuss how MRI is being used to assess peripheral nerve lesions in experimental and clinical contexts, including recent advances in the development of novel contrast media.
The autoimmune channelopathies are a group of neurological disorders in which patients develop autoantibodies to ion channels or related functional proteins. Camilla Buckley and Angela Vincent review the proposed roles of these antibodies in disease pathogenesis, and discuss how antibody measurement can aid the diagnosis and management of the autoimmune channelopathies.
Therapeutic monoclonal antibodies have shown considerable promise for the treatment of multiple sclerosis in animal models, but the translation of this approach to the clinic has been impeded by unexpected effects and adverse reactions. In this review, Reinhard Hohlfeld and Hartmut Wekerle discuss the current state of development of various monoclonal antibodies for the treatment of multiple sclerosis.
