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Shigella spp. that are resistant to almost all antimicrobial classes are increasing in prevalence and becoming globally dominant. The situation is critical and highlights a trend that is mirrored by other enteric bacterial pathogens. New interventions to prevent and treat these infections are essential to tackle a potential public health catastrophe.
In this study, Carfrae et al. show that inhibition of biotin and fatty acid synthesis restores colistin activity against Gram-negative bacteria and prevents colistin resistance.
In this study, Brown et al. show that nutrient deprivation increases Plasmodium falciparum survival and tolerance to the antimalarial drug artemisinin.
This study reports the identification of an inhibitor of a Toxoplasma gondii myosin motor protein that could be exploited to prevent or treat infections with T. gondii and other apicomplexan parasites.
This study reports a bacterial antiphage protein that contains a NACHT domain, which is also found in metazoan proteins that mediate immunity and inflammation.
This Genome Watch highlights how combining next-generation sequencing and imaging technologies sheds light on the diverse and intricate symbiotic relationships of uncultivated archaea and bacteria.
In this Review, Toyofuku, Schild, Kaparakis-Liaskos and Eberl discuss the different types of bacterial membrane vesicle, how they are formed, their structure and composition and their diverse functions.
In this Review, Brouwer et al. summarize recent developments in our understanding of Group A Streptococcus (GAS), focusing on the epidemiologic and clinical features of GAS infection and the molecular mechanisms associated with GAS virulence and drug resistance.
In this Review, Stelzner, Vollmuth and Rudel summarize current knowledge of Chlamydia trachomatis intracellular replication, its metabolism within the host cell and how it defends against host cell autonomous and innate immune responses, as well as its transition to a persistence state.
Crimean–Congo haemorrhagic fever (CCHF) is a severe and often lethal tick-borne illness that is caused by infection with the CCHF virus (CCHFV). In this Review, Hawman and Feldmann explore recent insights into the function of viral proteins in CCHFV pathogenesis, our current understanding of CCHF and the state of treatments and vaccines for CCHFV.
