Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Marine oxygen minimum zones are expanding globally as a result of rising temperatures. In this Progress article, Bertagnolli and Stewart describe the ecological and functional diversity of the microbial communities that inhabit these zones and their contribution to biogeochemical cycles.
In this Progress article, McGinn and Marraffini review recent studies that have advanced our understanding of the molecular mechanisms of spacer integration, protospacer capture and primed spacer acquisition, and discuss the future of the field.
Canonical two-component systems catalyse autophosphorylation of the histidine kinase, transfer of the phosphoryl group to the regulator and dephosphorylation of the phosphoregulator. In this Progress article, Jacob-Dubuisson and colleagues highlight recent structural insights into the signalling and catalytic mechanisms of sensor histidine kinases.
The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating consequences of ZIKV infection, particularly in pregnant women. In this Progress article, Barouch and colleagues discuss recent preclinical studies and lessons learned from first-in-human clinical trials with ZIKV vaccines.
In this Progress article, Collins and colleagues discuss how CRISPR-based analyses in genetically intractable microorganisms, including mycobacteria, fungi and parasites, have enabled the discovery of novel gene functions, the investigation of genetic interaction networks and the identification of virulence factors.
