Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Oral treatment withLactococcus lactismodified to secrete pro-insulin and IL-10, when combined with systemic low-dose CD3-specific antibodies, reverses diabetes in NOD mice.
In T cells, the kinase mTOR (mammalian target of rapamycin) integrates immune signals and metabolic cues to control T cell maintenance and activation. This Review describes the role of mTOR in determining T cell fate decisions and the implications of targeting mTOR in the treatment of disease.
Dendritic cells (DCs) are the master regulators of T cell responses to foreign antigens. This Review discusses how the tumour necrosis factor (TNF) superfamily of molecules influences DC biology and the outcome for T cell immune responses.
This Review argues against the historical view of the granuloma as a host-protective structure and provides evidence that the innate immune mechanisms of tuberculous granulomas are involved in the expansion and dissemination of infection.
Here, John MacMicking provides a broad overview of the recently described functional properties of interferon-inducible effector proteins that mediate cell-autonomous host defence against internalized bacteria, protozoa and viruses.
This article looks at the crosstalk between multipotent mesenchymal stromal cells (MSCs) and innate immunity, ranging from haematopoiesis to antimicrobial defences.